Zoonotic transmission of rotavirus: surveillance and control
| Autor: | Vito Martella, Krisztián Bányai, Szilvia L. Farkas, Renáta Dóró |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Diarrhea
Rotavirus Microbiology (medical) Protective immunity Molecular epidemiology Transmission (medicine) Reassortment Rotavirus Vaccines Genome Viral Biology medicine.disease_cause Microbiology Virology Animal origin Rotavirus Infections Interspecies transmission Infectious Diseases Zoonoses medicine Animals Humans medicine.symptom |
| Zdroj: | Expert Review of Anti-infective Therapy. 13:1337-1350 |
| ISSN: | 1744-8336 1478-7210 |
| DOI: | 10.1586/14787210.2015.1089171 |
| Popis: | Group A rotavirus (Rotavirus A, RVA) is the main cause of acute dehydrating diarrhea in humans and numerous animal species. RVA shows vast diversity and a variety of human strains share genetic and antigenic features with animal origin RVA strains. This finding suggests that interspecies transmission is an important mechanism of rotavirus evolution and contributes to the diversity of human RVA strains. RVA is responsible for half a million deaths and several million hospitalizations worldwide. Globally, two rotavirus vaccines are available for routine use in infants. These vaccines show a great efficacy profile and induce protective immunity against various rotavirus strains. However, little is known about the long-term evolution and epidemiology of RVA strains under selective pressure related to vaccine use. Continuous strain surveillance in the post-vaccine licensure era is needed to help better understand mechanisms that may affect vaccine effectiveness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|