Synthesis and antitubercular activity of novel 3,5-diaryl-4,5-dihydro-1H-pyrazole derivatives
| Autor: | K.R. Alagawadi, Dilip H. Dadwe, Shankar G. Alegaon |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Molecular Structure
Stereochemistry Proton Magnetic Resonance Spectroscopy Isoniazid Antitubercular Agents General Medicine Microbial Sensitivity Tests Mycobacterium tuberculosis Pyrazole In vitro Mass Spectrometry chemistry.chemical_compound Structure-Activity Relationship chemistry Drug Design Drug Discovery Mycobacterium tuberculosis H37Rv Spectroscopy Fourier Transform Infrared medicine Proton NMR Structure–activity relationship Molecule Pyrazoles Spectral data medicine.drug |
| Zdroj: | Drug research. 64(10) |
| ISSN: | 2194-9387 |
| Popis: | Novel 3,5-diaryl-4,5-dihydro-1H-pyrazole derivatives were efficiently synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv (MTB). The chemical structures of the compound were elucidated by elemental analysis, FTIR, (1)H NMR, and mass spectral data. Most of the title compounds have exhibited significant antitubercular activity. Compounds 4g, 4h, 4l, 4n and 4o showed pronounced antitubercular activity comparable to the reference isoniazid, whereas, compounds 4a, 4c, 4j, 4k, and 4p displayed good antitubercular activity. 5-(4-chlorophenyl)-4,5-dihydro-3-p-tolylpyrazol-1-yl-(6-methylimidazo[2,1-b]thiazol-5-yl)methanone (4g) was found to be the most promising compound with MIC values of 0.39 µg/ml. |
| Databáze: | OpenAIRE |
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