Effects of apolipoproteins on dalargin transport across the blood-brain barrier
| Autor: | D. A. Shamenkov, Renad N. Alyautdin, Petrov Ve |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Apolipoprotein E
Time Factors Apolipoprotein B Nanoparticle Polysorbates engineering.material Blood–brain barrier Polyvinyl alcohol General Biochemistry Genetics and Molecular Biology law.invention chemistry.chemical_compound Mice Apolipoproteins E Drug Delivery Systems Coating Coated Materials Biocompatible law Polymer chemistry medicine Animals Outbred Strains Animals Particle Size Apolipoproteins B Analgesics Drug Carriers biology Behavior Animal Biological Transport General Medicine Enbucrilate Enkephalin Leucine-2-Alanine medicine.anatomical_structure chemistry Cyanoacrylate Blood-Brain Barrier biology.protein engineering Nanoparticles Adsorption Nuclear chemistry |
| Zdroj: | Bulletin of experimental biology and medicine. 142(6) |
| ISSN: | 0007-4888 |
| Popis: | Antinociceptive activity of dalargin (7.5 mg/kg) adsorbed on poly(butyl)cyanoacrylate nanoparticles with different coating was studied on outbred albino mice by the tail-flick test. Poly(butyl)cyanoacrylate nanoparticles without coating did not increase the antinociceptive activity of dalargin and hence, did not increase its transport across the blood-brain barrier. Poly(butyl)cyanoacrylate nanoparticles coated with apolipoprotein B, apolipoprotein E, and polysorbate 80 increased the transport of dalargin across the blood-brain barrier. Delivery of dalargin to the brain was most effective in case of using poly(butyl)cyanoacrylate nanoparticles with polysorbate 80 coating and subsequent supercoating with apolipoprotein E. |
| Databáze: | OpenAIRE |
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