Secondary bacterial isolates from previously untreated Buruli ulcer lesions and their antibiotic susceptibility patterns in Southern Nigeria
Autor: | Chinenye Nwaekpe, Vitalis Ulodiaku, Charles C. Nwafor, Nelson O. Madichie, Adeniyi Hakeem Bisiriyu, Anthony O. Meka, Daniel C. Oshi, Martin Njoku, Chukwuka Alphonsus, Moses C. Anyim, Dare Fakiyesi, Ignatius Ejiofor, Obinna K Mbah, Ngozi Ekeke, Kingsley N. Ukwaja, Joseph N. Chukwu |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Microbiology (medical) Buruli ulcer Adult Male lcsh:Arctic medicine. Tropical medicine Adolescent medicine.drug_class Klebsiella pneumoniae lcsh:RC955-962 030231 tropical medicine 030106 microbiology Antibiotics Nigeria Microbial Sensitivity Tests medicine.disease_cause Gram-Positive Bacteria Microbiology 03 medical and health sciences Young Adult 0302 clinical medicine Gram-Negative Bacteria medicine Chemotherapy Humans Mycolactones Prospective Studies Child Buruli Ulcer biology Mycobacterium ulcerans business.industry Pseudomonas aeruginosa Coinfection Middle Aged biology.organism_classification Antimicrobial medicine.disease Anti-Bacterial Agents Aeromonas hydrophila Infectious Diseases Staphylococcus aureus Wounds Parasitology Female business Bacterial contamination |
Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical, Volume: 49, Issue: 6, Pages: 746-751, Published: DEC 2016 Revista da Sociedade Brasileira de Medicina Tropical v.49 n.6 2016 Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT Revista da Sociedade Brasileira de Medicina Tropical, Vol 49, Iss 6, Pp 746-751 |
ISSN: | 1678-9849 |
Popis: | INTRODUCTION: Mycolactones, secreted by Mycobacterium ulcerans, were previously believed to prevent super infection in Buruli ulcer lesions. However, little is known about secondary bacterial infections in these lesions. This study evaluated contaminating bacterial flora and their antibiotic susceptibility patterns in cases of previously untreated Buruli ulcer disease from three states in Southern Nigeria. METHODS A prospective analysis was conducted between January and June of 2015 using wound swabs from eligible patients with Buruli ulcer disease, confirmed by quantitative-polymerase chain reaction, with active ulcers. Microbiological analyses including isolation of bacteria, species identification of isolates, and drug susceptibility tests were performed. RESULTS Of 51 patients, 27 (52.9%) were female. One or more bacterial species of clinical importance was isolated from each patient. A total of 17 different microbial species were isolated; 76.4% were Gram-negative and 23.6% were Gram-positive isolates. The most common bacterial species detected was Staphylococcus aureus (24%), followed by Aeromonas hydrophila (13%), Pseudomonas aeruginosa (13%), and Klebsiella pneumoniae (11%). Drug susceptibility tests showed a particularly high frequency of resistance to commonly used antimicrobials in Nigeria for Staphylococcus aureus. CONCLUSIONS Super bacterial infections occur in Buruli ulcer lesions in Nigeria, and these infections are associated with high rates of resistance to commonly used antibiotics in the country. |
Databáze: | OpenAIRE |
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