Simultaneous diffuse sclerosis variant of papillary thyroid carcinoma and diffuse toxic hyperplasia (Graves' disease)
| Autor: | Virginia A. LiVolsi, Steven A. DeJong, Jennifer L. Hunt, Marlyn C. Ciesla, Gladell P. Paner |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Graves' disease Pathology and Forensic Medicine Thyroid carcinoma Diagnosis Differential Endocrinology medicine Carcinoma Humans Thyroid Neoplasms business.industry Thyroid Thyroidectomy Nodule (medicine) General Medicine Hyperplasia medicine.disease Carcinoma Papillary Graves Disease medicine.anatomical_structure Thyrotoxicosis Female Differential diagnosis medicine.symptom business |
| Zdroj: | Endocrine pathology. 15(1) |
| ISSN: | 1046-3976 |
| Popis: | Diffuse sclerosis variant of papillary thyroid carcinoma (DSVPTC) is an unusual malignant neoplasm that typically permeates the entire gland resulting in diffuse thyroid enlargement. In the absence of a dominant nodule, DSVPTC can be histologically deceiving because of exuberant inflammation and the scattered distribution of the microscopic tumor islands. The difficulty in diagnosing this tumor is compounded by its rarity and unusual clinical and histologic features. Herein, we describe a unique case of DSVPTC that was clinically masked by a co-existing second diffuse thyroid process--Graves' disease (GD). A subtotal thyroidectomy was performed in a 27-yr-old Caucasian female who presented with symmetrical diffuse thyromegaly with neck compressive symptoms, thyrotoxicosis, and biochemical signs of GD. Histologic examination of the thyroid gland unexpectedly revealed extensive involvement by DSVPTC in addition to the diffuse hyperplastic non-malignant thyroid follicles. This report illustrates the histologic features as well as the diagnostic challenge encountered in a rare simultaneous occurrence of DSVPTC and GD.P |
| Databáze: | OpenAIRE |
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