Viral Expression Directs the Fate of B Cells in Bovine Leukemia Virus-Infected Sheep
| Autor: | Carole François, Arnaud Florins, Luc Willems, Amel-Baya Bouzar, Marjet Elemans, Becca Asquith, Alix de Brogniez, Michal Reichert |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Gene Expression Regulation
Viral animal diseases viruses Immunology Cattle Diseases Microbiology Immune system In vivo Virology Leukemia Virus Bovine Animals B-Lymphocytes Sheep Bovine leukemia virus biology Host (biology) biochemical phenomena metabolism and nutrition Enzootic Bovine Leukosis biology.organism_classification Genome Replication and Regulation of Viral Gene Expression Viral replication Virus type Insect Science Cattle Ex vivo |
| Popis: | The host immune response is believed to tightly control viral replication of deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV). However, this assumption has not been definitely proven in vivo . In order to further evaluate the importance of the immune response in the BLV model, we studied the fate of cells in which viral expression was transiently induced. Using a dual fluorochrome labeling approach, we showed that ex vivo induction of viral expression induces higher death rates of B cells in vivo . Furthermore, cyclosporine treatment of these animals indicated that an efficient immune response is required to control virus-expressing cells. |
| Databáze: | OpenAIRE |
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