Meningeal cells influence cerebellar development over a critical period
| Autor: | Martin Berry, Christina von Knebel Doeberitz, F. W. Pehlemann, Jobst Sievers |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Aging
Embryology Cerebellum Pathology medicine.medical_specialty Ontogeny Biology Extracellular matrix Hydroxydopamines chemistry.chemical_compound Meninges Cricetinae medicine Animals Primordium Oxidopamine Glia limitans Mesocricetus Cell Biology Anatomy medicine.anatomical_structure Animals Newborn nervous system chemistry Cerebellar cortex Cerebellar vermis Developmental Biology |
| Zdroj: | Anatomy and Embryology. 175:91-100 |
| ISSN: | 1432-0568 0340-2061 |
| DOI: | 10.1007/bf00315459 |
| Popis: | We have investigated the influence of meningeal cells on the development of the cerebellum by destroying these cells with 6-hydroxydopamine in hamsters of different ages. The ensuing foliation and lamination disruption in the cerebellar vermis is attributed to a disintegration of the cerebellar surface and a disorganization of the glial scaf-fold of the cerebellar cortex due to a loss of meningeal-glial interaction in stabilizing the extracellular matrix at the glia limitans superficialis (v. Knebel Doeberitz et al. 1986, Neuroscience 17:409–426). The severity of these cerebellar defects is correlated with the ontogenetic stage at which meningeal cells are destroyed, being greatest after treatment at postnatal day 1 and decreasing thereafter until day 5 and beyond, when no abnormalities occur, although all meningeal cells are destroyed throughout. The absence of cerebellar defects after destruction of meningeal cells at day 5 or later is associated firstly with the end of the period of branching morphogenesis of the cerebellum when all folial primordia are established, and, secondly, with the maturation of the glia limitans superficialis. These findings indicate that meningeal cells stabilize the cerebellar surface and glial scaffold over a critical period that ends, when the pattern of cerebellar foliation is established, and when the glia limitans superficialis has reached a mature state. Beyond this stage glial end-feet alone are sufficient to maintain the epithelial integrity of the cerebellum. |
| Databáze: | OpenAIRE |
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