Chronic pulmonary infection caused by mycoplasma pneumoniae leading to pulmonary arteriole remodeling and pulmonary hypertension in rats
| Autor: | Liu Dong-xu, Peng Dong-xin, Zhao Shi-yu, Chen Ru, Lei Han-ti, Che Dongyuan |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Pathology medicine.medical_specialty Mycoplasma pneumoniae Hypertension Pulmonary medicine.disease_cause Right ventricular hypertrophy Arteriole Management of Technology and Innovation medicine.artery Internal medicine Pneumonia Mycoplasma medicine Animals Rats Wistar Lung business.industry Respiratory infection medicine.disease Pulmonary hypertension Rats Arterioles Pneumonia Chronic Disease Pulmonary artery Cardiology business Type I collagen |
| Zdroj: | Journal of Tongji Medical University. 15:223-226 |
| ISSN: | 0257-716X |
| DOI: | 10.1007/bf02887950 |
| Popis: | The pulmonary arteriole remodeling in Wistar rats with respiratory infection induced by mycoplasma pneumoniae was observed using light microscopy and morphometry. The pulmonary artery pressure (PAP) and index of right ventricular hypertrophy (RVHI) were measured. The intimal and medial hypertrophy can be seen in the pulmonary arterioles, leading to vessel wall thickening and narrowing of the lumina. The total number of the pulmonary arterioles decreased (P0.01), and both pulmonary hypertension (Ppa 4.11 +/- 0.19 kPa) and right ventricular hypertrophy (RVHI = 34.96 +/- 3.91%) occurred. In addition, an interstitial pulmonary fibrosis (IPF) was found, in which the content of collagen in the lung tissue changed, i. e., type I collagen increased whereas type III one decreased, and the ratio of type I collagen to type III one increased. It suggested that respiratory infection induced by repeated MP may result in remodeling of pulmonary arterioles and are closely related to pulmonary hypertension. |
| Databáze: | OpenAIRE |
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