Squamous intraepithelial lesions of the anal squamocolumnar junction: Histopathological classification and HPV genotyping
| Autor: | Silvia de Sanjosé, Omar Clavero, Vicente Marco Molina, Jenny McCloskey, Ville Pimenoff, Beatriz Quirós, Ignacio G. Bravo, F. Xavier Bosch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Hpv genotypes HPV medicine.medical_specialty Pathology Hpv genotyping Papillomaviruses Low-grade squamous intraepithelial lesion (LSIL) Human immunodeficiency virus (HIV) medicine.disease_cause Article Epithelium lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Virology medicine Anal cancer lcsh:RC109-216 Human papillomavirus Papil·lomavirus business.industry Squamocolumnar Junction HIV virus diseases medicine.disease Anal squamocolumnar junction 030104 developmental biology Infectious Diseases Papillary immature metaplasia (PIM) 030220 oncology & carcinogenesis Anal warts Histopathology business High-grade squamous intraepithelial lesion (HSIL) Epiteli |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona Papillomavirus Research, Vol 3, Iss, Pp 11-17 (2017) Papillomavirus Research |
| Popis: | Background Human papillomavirus (HPV)-related anal cancer lesions are often found adjacent to the squamocolumnar junction (SCJ). We have assessed the histopathology and associated HPV genotypes in anal SCJ lesions in surgically excised anal warts in HIV-negative and –positive patients. Methods Histopathology identified 47 squamous intraepithelial lesions (SILs) adjacent to the SCJ amongst a total of 145 cases of clinically diagnosed anal condylomata. The anal SCJ lesions were further analyzed with p16, CK7 and p63 immunohistochemistry and HPV genotyping. Results Sixteen (16/47) of the excised anal wart lesions contained HSIL; Three were HSIL and exclusively associated with oncogenic HPVs. A further thirteen (13/47) were mixed lesions. Of these eight were HSILs with LSIL and six were HSILs with papillary immature metaplasia (PIM); Ten of the mixed lesions were associated with one or more oncogenic HPVs, while three cases were exclusively associated with HPV6. Conclusions Clinically diagnosed anal warts cannot be assumed to be limited to low-grade lesions as anal warts of the SCJ often show heterogeneous lesions, with coexistence of LSIL, PIM, and HSIL. Lesions showing PIM, however, may mimic HSIL, because they are hypercellular, but lack the nuclear atypia and conspicuous mitotic activity of HSIL; and are p16 negative. Highlights • Anal warts of the SCJ are often heterogeneous; with LSIL, including PIM and HSIL. • Anal HSILs only with HPV6 may indicate that LR-HPVs have some role in oncogenesis. • Recognition of PIM is important given its potential for being confused with HSIL. • Clinical diagnosis of anal warts cannot be assumed to be limited to LSIL. • Microscopic examination of anal warts is encouraged with appropriate immunostains. |
| Databáze: | OpenAIRE |
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