In for the long-haul? Seropositivity and sequelae 1 year post COVID-19

Autor: Jeremy W. Deuel, Patricia Schlagenhauf
Přispěvatelé: Deuel, Jeremy Werner [0000-0002-5409-7712], Apollo - University of Cambridge Repository, University of Zurich, Deuel, Jeremy Werner
Rok vydání: 2021
Předmět:
Zdroj: BMC Medicine, Vol 19, Iss 1, Pp 1-2 (2021)
BMC Medicine
ISSN: 1741-7015
Popis: We assessed the duration and baseline determinants of antibody responses to SARS-CoV-2 spike antigens and the occurrence of reinfections in a prospective cohort of 173 Spanish primary health care worker patients followed initially for 9 months and subsequently up to 12.5 months after COVID-19 symptoms onset. Seropositivity to SARS-CoV-2 spike and receptor-binding domain antigens up to 149-270 days was 92.49% (90.17% IgG, 76.3% IgA, 60.69% IgM). In a subset of 64 health care workers who had not yet been vaccinated by April 2021, seropositivity was 96.88% (95.31% IgG, 82.81% IgA) up to 322-379 days post symptoms onset. Four suspected reinfections were detected by passive case detection, two among seronegative individuals (5 and 7 months after the first episode), and one low antibody responder. Antibody levels significantly correlated with fever, hospitalization, anosmia/hypogeusia, allergies, smoking, and occupation. Stable sustainment of IgG responses raises hope for long-lasting COVID-19 vaccine immunity.
Databáze: OpenAIRE
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