Determination of oxidative protein and lipid damage in adult hypopituitary patients with GH deficiency
| Autor: | Ufuk Çakatay, Nese Ozbey, S. Molvalilar, A Yurci, Ayşe Telci |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Lipid Peroxides medicine.medical_specialty Antioxidant Endocrinology Diabetes and Metabolism medicine.medical_treatment Hypopituitarism Oxidative phosphorylation medicine.disease_cause Body fat percentage Statistics Nonparametric Endocrinology Internal medicine medicine Humans Sulfhydryl Compounds chemistry.chemical_classification Anthropometry Human Growth Hormone business.industry medicine.disease Lipoproteins LDL Oxidative Stress Blood pressure chemistry Body Composition Thiol Tyrosine Female lipids (amino acids peptides and proteins) business Oxidized ldl Oxidative stress |
| Zdroj: | Journal of Endocrinological Investigation. 26:1001-1007 |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03348199 |
| Popis: | The aim of this study is to determine oxidative protein and lipid damage in adult hypopituitary GH-deficient patients. Eighteen hypopituitary GH-deficient--otherwise healthy-adults on conventional replacement therapy other than GH (9 male, 9 female, age 41.8 +/- 16.4 yr) and 18 healthy subjects (6 male, 12 female, age 40.3 +/- 16.2 yr) participated in the study. Plasma products of oxidative protein damage [protein carbonyl (PCO) and nitrotyrozine (NT)], plasma oxidized LDL (oxLDL), plasma product of oxidative lipid damage [lipid hydroperoxide (LHP)] and antioxidant status of the plasma [total thiol (T-SH)] were measured. Body fat percentage, total and LDL-cholesterol concentrations were significantly higher in the hypopituitary group. Plasma PCO, NT, LHP and T-SH concentrations did not differ significantly between patients and controls. OxLDL concentration was significantly higher in the hypopituitary patients (62.4 +/- 17.8 vs 43.1 +/- 11.3 U/l, p = 0.001). In the patients, oxLDL correlated significantly with the duration of hypopituitarism (r = 0.6323, p = 0.01). In the controls, oxLDL correlated significantly with blood pressure, total and VLDL-cholesterol concentrations. Increased oxLDL concentration may indicate increased oxidative stress within the vascular compartment and may contribute to the proatherogenic state in GH-deficient hypopituitary patients independent from conventional risk factors. |
| Databáze: | OpenAIRE |
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