Regulation of AMPA receptors during synaptic plasticity

Autor:	Richard L. Huganir, Insuk Song
Rok vydání:	2002
Předmět:	Neuronal Plasticity Synaptic scaling General Neuroscience Nonsynaptic plasticity Kainate receptor Biology Cell biology Synaptic fatigue Synapses Synaptic plasticity Metaplasticity Animals Humans Receptors AMPA Long-term depression Neuroscience Ion channel linked receptors
Zdroj:	Trends in Neurosciences. 25:578-588
ISSN:	0166-2236
DOI:	10.1016/s0166-2236(02)02270-1
Popis:	Ionotropic neurotransmitter receptors mediate rapid synaptic transmission in the CNS and PNS. Owing to this central role in trans-synaptic signal transduction, modulation of these receptors could play a crucial role in the expression of synaptic plasticity in the brain. AMPA receptors mediate the majority of rapid excitatory synaptic transmission in the CNS. Recent studies have indicated that the activity and synaptic distribution of these receptors is dynamically regulated and could be crucial for the short- and long-term modification of synaptic efficacy. Here we review recent data on the molecular mechanisms that underlie the modulation of AMPA receptors and the role of AMPA-receptor regulation in mediating synaptic plasticity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19593a1ba9ece9bb890e624e24ec866d https://doi.org/10.1016/s0166-2236(02)02270-1 Zobrazit plný text záznamu Full Text from ScienceDirect