Clinical and laboratory associations of mannose-binding lectin in 219 adults with IgG subclass deficiency

Autor: Luigi F. Bertoli, Jackson C. Barton, James C. Barton
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Adult
Male
Risk
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty
Respiratory tract infection
Immunology
chemical and pharmacologic phenomena
IgG subclass deficiency
Logistic regression
Gastroenterology
Subclass
White People
Autoimmune Diseases
Atopy
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Internal medicine
Lower respiratory tract infection
Diabetes mellitus
medicine
Prevalence
Humans
IgG Deficiency
Sinusitis
Respiratory Tract Infections
Mannan-binding lectin
Retrospective Studies
Mannose-binding lectin
business.industry
Pneumonia
Middle Aged
medicine.disease
bacterial infections and mycoses
United States
030104 developmental biology
Upper respiratory tract infection
Immunoglobulin G
Female
business
lcsh:RC581-607
Body mass index
Metabolism
Inborn Errors
030215 immunology
Research Article
Zdroj: BMC Immunology, Vol 20, Iss 1, Pp 1-8 (2019)
BMC Immunology
ISSN: 1471-2172
Popis: Background Mannose-binding lectin (MBL) deficiency may increase risk of respiratory tract infection in adults unselected for IgG or IgG subclass levels. In a retrospective study, we sought to determine associations of serum MBL levels with clinical and laboratory characteristics of unrelated non-Hispanic white adults at diagnosis of IgG subclass deficiency (IgGSD). We computed the correlation of first and second MBL levels expressed as natural logarithms (ln) in a patient subgroup. We compared these characteristics of all adults with and without MBL ≤50 ng/mL: age; sex; body mass index; upper/lower respiratory tract infection; diabetes; autoimmune condition(s); atopy; other allergy; corticosteroid therapy; and subnormal serum IgG subclasses, IgA, and IgM. We performed logistic regression on MBL ≤50 ng/mL (dichotomous) using the three independent variables with the lowest values of p in univariate comparisons. Results There were 219 patients (mean age 51 ± 13 y; 82.5% women). Thirty-six patients (16.4%) had MBL ≤50 ng/mL. Two MBL measurements were available in 14 patients. The median interval between the first and second measurements was 125 d (range 18–1031). For ln-transformed data, we observed adjusted r2 = 0.9675; Pearson correlation coefficient 0.9849; and p
Databáze: OpenAIRE
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