A novel Salvialactomine from the callus culture of Salvia santolinifolia Boiss
| Autor: | Tour Jan, Akhtar Muhammad, Said Nadeem, Raiha Qadri, Achyut Adhikari, Beena Naqvi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Plant Science Salvia 01 natural sciences Biochemistry Analytical Chemistry HeLa Murashige and Skoog medium Cell Line Tumor Cervical carcinoma Humans Bony Callus Furans IC50 Molecular Structure Traditional medicine biology 010405 organic chemistry Chemistry Organic Chemistry Prostatic Neoplasms biology.organism_classification Salvia santolinifolia Antineoplastic Agents Phytogenic Culture Media 0104 chemical sciences 010404 medicinal & biomolecular chemistry Callus Lamiaceae Drug Screening Assays Antitumor HeLa Cells |
| DOI: | 10.6084/m9.figshare.4880369 |
| Popis: | A novel compound Salvialactomine (1) along with two other unusual occurring natural products Pentatriacontanoic acid 1, 3-dihydroxypropyl ester (2) and 5-Methylflavone (3) were isolated from the callus of Salvia santolinifolia Boiss. Callus was initiated on MS medium containing NAA (0.5 mg/L) and further sub-cultured on MS medium supplemented with NAA with BA (0.5 + 1.5 mg/L). The structures of isolated compounds were determined by using mass spectrometry, 1D, and 2D–NMR techniques. Compounds 1, and 3 were tested for two different cancer cell lines, i.e. Hela (Cervical cancer cell) and PC-3 (Prostate cancer cells). IC50 was found as > 30 using Doxorobicin (0.912 ± 0.12 μmol L−1) as a standard. |
| Databáze: | OpenAIRE |
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