Sus Scrofa immune tissues as a new source of bioactive substances for skin wound healing
| Autor: | A. A. Basov, N. M. Murashova, L. V. Fedulova, S. S. Dzhimak, Ekaterina R. Vasilevskaya, Ekaterina Trofimova |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0301 basic medicine food.ingredient Skin wound Scars Wound healing Pharmacology 01 natural sciences Lecithin 03 medical and health sciences food Immune system medicine BALB/c mice lcsh:QH301-705.5 Wound treatment Chemistry Protein-peptide complex Resorption Skin regeneration 030104 developmental biology lcsh:Biology (General) Original Article medicine.symptom General Agricultural and Biological Sciences 010606 plant biology & botany Animal skin |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 28, Iss 3, Pp 1826-1834 (2021) Saudi Journal of Biological Sciences |
| Popis: | Influence of a new protein-peptide complex on promoting skin wound healing in male BALB/c mice was studied. Protein-peptide complex, extracted from Sus scrofa immune organs, was percutaneously administered using two methods: by lecithin gel-like liquid crystals and by liquid microemulsion. On the fifth day, wound closure in mice with a linear wound model become faster in group (less 2 days comparison to other ones), which was treated with lecithin liquid crystals carrying the protein-peptide complex. This promoting healing can be caused by resorption of bioactive high-molecular compounds the animal skin. In mice with the linear wound model, the tensile strength of the scars were respectively higher both in mice, treated using lecithin liquid crystals with protein-peptide complex, and in mice, treated using microemulsion containing protein-peptide complex, by 215.4% and 161.5% relative to the animals, which did not receive bioactive substances for wound treatment. It was associated with the regeneratory effects of tissue- and species-specific protein-peptide complexes, including α-thymosin Sus scrofa (C3VVV8_PIG, m/z 3802.8) and other factors, which were described as parts of the new extracted complex. This reveals that percutaneous administration of the complex reliably activates local regenerative processes in animals. |
| Databáze: | OpenAIRE |
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