Moderate exercise and fibrinolytic potential in obese sedentary men with metabolic syndrome
| Autor: | C. Ira Packianathan, Catherine J. van Blerk, Nick Finer, Penelope J. Morris |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Myocardial Infarction Medicine (miscellaneous) Ethnic origin Tissue plasminogen activator Endocrinology Oxygen Consumption Risk Factors Internal medicine Fibrinolysis Plasminogen Activator Inhibitor 1 medicine Ethnicity Humans Myocardial infarction Obesity Exercise physiology Exercise Metabolic Syndrome business.industry Incidence (epidemiology) Smoking Public Health Environmental and Occupational Health Thrombosis medicine.disease Tissue Plasminogen Activator Cardiology Observational study Metabolic syndrome business Food Science medicine.drug |
| Zdroj: | Obesity research. 11(11) |
| ISSN: | 1071-7323 |
| Popis: | Objective: To investigate the impact of 30-minute walking exercise at 70% Vo2max on tissue plasminogen activator (t-PA) Ag and plasminogen activator inhibitor type 1 (PAI-1) Ag in obese sedentary males. Research Methods and Procedures: A controlled observational study of the effect of a 30-minute acute exercise bout at 70% Vo2max on plasma t-PA antigen and PAI-1 antigen in 10 obese sedentary males matched for age, ethnic origin, and smoking status with 10 nonobese sedentary male controls. Results: The obese group remained hypofibrinolytic compared with the nonobese group at all time-points before, during, and after exercise. t-PA increased in both groups with exercise before returning to baseline values 30 minutes after exercise. PAI-1 did not significantly change in either group with exercise but rose significantly 30 minutes after exercise in the obese group. Discussion: The reduction in fibrinolytic potential in the obese group represents an increase in acute thrombotic risk and could account for the increased incidence of exercise-associated myocardial infarction observed in sedentary obese groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text