Value of silicone gel in prevention of cobblestoning following punch minigrafting in vitiligo
| Autor: | Tag S. Anbar, Zeinab M. El Maadawi, Noha Farouk, Dalia Ahmed Bassiouny, Talal Abd El Raheem, Mohamed Hassan, Marwa M. Fawzy |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cicatrix Hypertrophic Vitiligo Skin Pigmentation Dermatology Silicone Gels 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Silicone medicine Humans 030203 arthritis & rheumatology Wound Healing business.industry Skin Transplantation Grafting medicine.disease Treatment Outcome surgical procedures operative chemistry Ultraviolet Therapy business Complication Value (mathematics) |
| Zdroj: | Journal of Dermatological Treatment. 33:306-313 |
| ISSN: | 1471-1753 0954-6634 |
| DOI: | 10.1080/09546634.2020.1751038 |
| Popis: | Cobblestoning is the most common complication of minipunch grafting.To assess the value of silicone gel application following minipunch grafting and the histopathological and immunohistochemical changes in cases with cobblestoning.Minipunch grafting was performed in two similar vitiligo lesions in 27 cases with stable vitiligo. After healing, silicone gel was applied twice daily on one lesion while zinc oxide ointment was applied to the other lesion serving as a control. Four biopsies were taken from each case; normal, vitiliginous skin before treatment and the two treated lesions 3 months after therapy, for histopathology and immunohistochemical staining for MMP9tenascin-C.Repigmentation occurred in 19 cases (70.7%). The number of lesions showing excellent and good response was significantly higher on the silicone gel side (Silicone gel application after minigrating improved the final response with no significant effect on the occurrence of cobblestoning. Cobblestoning resembled hypertrophic scarring histopathologically. |
| Databáze: | OpenAIRE |
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