A comparative profile of the prevalence and age distribution of human papillomavirus type 16/18 infections among three states of India with focus on northeast India
| Autor: | Chandralekha Duttagupta, S. Mukhopadhyay, Th. Dhabali Singh, R. Das, Sharmila Sengupta, Sudipta Roy, P. Laikangbam, Paramita Bhattacharya, Y. Verma |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Veterinary medicine India Cervix Uteri Hpv prevalence Age groups Prevalence Humans Medicine Human papillomavirus Human papillomavirus 16 Human papillomavirus 18 Traditional medicine business.industry Papillomavirus Infections Age Factors HPV infection Obstetrics and Gynecology Cervical cytology Middle Aged medicine.disease Eastern india Oncology DNA Viral Female West bengal Age distribution business |
| Zdroj: | International Journal of Gynecologic Cancer. 17:107-117 |
| ISSN: | 1525-1438 1048-891X |
| DOI: | 10.1111/j.1525-1438.2007.00827.x |
| Popis: | Human papillomavirus (HPV) DNA in cervical scrape samples of married women from Manipur (n= 692) and Sikkim (n= 415) in northeast India was determined and compared with that of women from West Bengal (n= 1112) in eastern India by polymerase chain reaction. HPV prevalence was lower in Manipur (7.4%) than in Sikkim (12.5%), which was closely followed by West Bengal (12.9%). HPV18 was predominant in Manipur (2.03%) and strikingly lower (0.2%) in Sikkim and West Bengal (0.9%), while the reverse was true for HPV16. The proportion of HPV16/18 infections in Manipur (3.3%, 22/672) and Sikkim (3.89%, 14/359) were comparable and significantly lower compared to that in West Bengal (7.8%, 79/1007) among women having normal cervical cytology. Such prevalence was similar among all age groups in Manipur: increased with age for women in Sikkim and dropped with age for those in West Bengal similar to that reported previously. At age ≤30 years, HPV16/18 prevalence in Manipur (3.3%) and Sikkim (2.5%) was comparable but was significantly lower (P < 0.05) in contrast to that in West Bengal (8.8%). Among abnormal cytologic lesions, HPV16/18 infections were significantly higher than in normals (P= 0.000) both in Sikkim (14.3%) and West Bengal (20.9%) and absent in Manipur. Such prevalence was noted among women in Sikkim aged >30 years and equally among those in West Bengal aged ≤30 or >30 years. Thus, women from northeast India, particularly from Manipur, appear less susceptible to HPV16/18 infection and related cervical lesions compared to those from West Bengal, where such proneness was prominently evident at age ≤30 years. |
| Databáze: | OpenAIRE |
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