Effects of alpha-lipoic acid on high fructose induced hepatic pathology

Autor: M Ozgocmen, Senay Topsakal, Ozlem Ozmen
Rok vydání: 2019
Předmět:
0301 basic medicine
antioxidant
Animals
Antioxidants/*pharmacology
Apoptosis/drug effects
Chemical and Drug Induced Liver Injury/*prevention & control
Female
Hepatocytes/drug effects
High Fructose Corn Syrup/*toxicity
Random Allocation
Rats
Rats
Wistar
Sweetening Agents/*toxicity
Thioctic Acid/administration & dosage/*pharmacology
Alpha-Lipoic Acid
Apoptosis
Pharmacology
Wistar rat
medicine.disease_cause
Antioxidants
fructose
Pathogenesis
chemistry.chemical_compound
0302 clinical medicine
corn syrup
thioctic acid
hepatic damage
oxidative stress
rat
animal
Thioctic Acid
drug effect
liver cell
food and beverages
General Medicine
toxic hepatitis
Corn syrup
Medical Laboratory Technology
female
030220 oncology & carcinogenesis
Chemical and Drug Induced Liver Injury
Alpha-lipoic acid
Histology
food.ingredient
randomization
liver
03 medical and health sciences
food
medicine
030102 biochemistry & molecular biology
High-fructose corn syrup
Fructose
Hepatic toxicity
chemistry
Sweetening Agents
High fructose
Hepatocytes
pathology
sweetening agent
High Fructose Corn Syrup
Oxidative stress
Zdroj: Biotechnichistochemistry : official publication of the Biological Stain Commission. 94(4)
ISSN: 1473-7760
Popis: Little is known about the pathogenesis of high fructose corn syrup (HFCS) induced hepatic toxicity. We investigated hepatic lesions induced by chronic HFCS consumption and the protective effects of alpha-lipoic acid (ALA) on liver pathology. We used 24 rats allocated randomly into three groups of eight. The HFCS group was given in drinking water for 10 weeks. The ALA + HFCS group was given the same dose of HFCS and ALA also was administered during the last 6 weeks of the experiment. The control group was untreated. The rats were euthanized at the end of 10 weeks and 24 h after the last ALA administration. A significant increase was observed in the serum aspartate aminotransferase (AST) level of the HFCS group compared to controls. Tissue malondialdehyde (MDA) levels also increased significantly and catalase (CAT) activity decreased significantly in the HFCS group. Caspase-3 expression increased significantly in the HFCS group compared to controls. In the ALA treated group, the levels of MDA, CAT and caspase-3 returned to near control levels. HFCS caused hepatic toxicity by increasing oxidative stress and apoptosis. ALA administration ameliorated the pathological changes. © 2018, © 2018 The Biological Stain Commission.
Databáze: OpenAIRE
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