Stability studies on some benzocycloheptane antihistaminic agents
| Autor: | E.A. Gadkariem, H. A. El-Obeid, M. A. Abounassif |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Drug
Ketotifen Chromatography Light Chemistry media_common.quotation_subject Clinical Biochemistry Pharmaceutical Science Loratadine Ascorbic acid High-performance liquid chromatography Dosage form Analytical Chemistry Benzocycloheptenes Drug Stability Drug Discovery Histamine H1 Antagonists medicine Ketotifen Fumarate Photodegradation Spectroscopy media_common medicine.drug |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 36:1011-1018 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/j.jpba.2004.09.019 |
| Popis: | The photostability of selected benzocycloheptane antihistaminic agents, namely, loratadine (I), pizotifen (II), ketotifen fumarate (III) and cyproheptatidine (IV), was investigated. Both I and II were photolabile while III and IV were photostable. To perform stability studies on the photolabile compounds (I and II), specific stability-indicating high performance liquid chromatographic (HPLC) methods were established. The accuracy, precision and reliability of the developed HPLC methods for the assay of I and II in their pharmaceutical dosage forms were reported. Assay results for both drugs were within R.S.D. values |
| Databáze: | OpenAIRE |
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