Diets with low n-6:n-3 PUFA ratio protects rats from fructose-induced dyslipidemia and associated hepatic changes: Comparison between 18:3 n-3 and long-chain n-3 PUFA

Autor: Sugeedha Jeyapal, Ahamed Ibrahim, Siva Sankara Vara Prasad Sakamuri, Anil Sakamuri, Suryam Reddy Kona
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
Linoleic acid
Clinical Biochemistry
030209 endocrinology & metabolism
Fructose
medicine.disease_cause
Linoleic Acid
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
11-beta-Hydroxysteroid Dehydrogenase Type 1
medicine
Animals
Rats
Wistar
Dyslipidemias
Inflammation
chemistry.chemical_classification
030109 nutrition & dietetics
alpha-Linolenic acid
Hypertriglyceridemia
alpha-Linolenic Acid
food and beverages
Cell Biology
medicine.disease
Eicosapentaenoic acid
eye diseases
Diet
Rats
Oxidative Stress
Endocrinology
Gene Expression Regulation
Liver
chemistry
Docosahexaenoic acid
lipids (amino acids
peptides
and proteins)
sense organs
human activities
Dyslipidemia
Oxidative stress
Polyunsaturated fatty acid
Zdroj: Prostaglandins, Leukotrienes and Essential Fatty Acids. 155:102082
ISSN: 0952-3278
DOI: 10.1016/j.plefa.2020.102082
Popis: In the present study, we investigated the impact of substituting alpha-linolenic acid (ALA) or long-chain n-3 PUFA (eicosapentaenoic acid and docosahexaenoic acid) for linoleic acid and hence decreasing n-6:n-3 PUFA ratio on high-fructose diet-induced hypertriglyceridemia and associated hepatic changes. Weanling male Wistar rats were divided into four groups and fed with starch-diet (n-6:n-3 PUFA ratio 215:1) and high-fructose diets with different n-6:n-3 PUFA ratio (215:1, 2:1 with ALA and 5:1 with long-chain n-3 PUFA) for twenty-four weeks. Substitution of linoleic acid with ALA (n-6:n-3 PUFA ratio of 2) or long-chain n-3 PUFA (n-6:n-3 PUFA ratio of 5) protected the rats from fructose-induced dyslipidemia, hepatic oxidative stress and corrected lipogenic and proinflammatory gene expression. Both ALA and long-chain n-3 PUFA supplementation also reversed the fructose-induced upregulation of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) gene, which is involved in the generation of active glucocorticoids in tissues. Although both ALA and LC n-3 PUFA prevented fructose-induced dyslipidemia to a similar extent, compared to ALA, LC n-3 PUFA is more effective in preventing hepatic oxidative stress and inflammation.
Databáze: OpenAIRE
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