Evolution in HLA-DRB1 and major histocompatibility complex class II haplotypes of Australian aborigines definition of a new DRB1 allele and distribution of DRB 1 gene frequencies
| Autor: | Carolyn Katovich Hurley, James McCluskey, Susana Cassidy, Gregory Bennett, Barry Boettcher, lan Humphreys, Susan C. Lester |
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| Rok vydání: | 1995 |
| Předmět: |
Native Hawaiian or Other Pacific Islander
Intragenic recombination Molecular Sequence Data Immunology Population Biology HLA-DQ alpha-Chains Gene Frequency HLA-DQ Antigens HLA-DQ beta-Chains Humans Immunology and Allergy Amino Acid Sequence Allele education Gene HLA-DRB1 Genetics education.field_of_study Major Histocompatibility Complex Class II Base Sequence Haplotype Australia HLA-DR Antigens General Medicine Biological Evolution Haplotypes HLA-DRB3 Chains HLA-DRB1 Chains |
| Zdroj: | Human Immunology. 42:154-160 |
| ISSN: | 0198-8859 |
| Popis: | The distribution of HLA-DRB1 alleles was studied in Australian aborigines from different parts of Australia. There were significant differences in the frequencies of DRB1 ∗ 0412, 1409, and 1410 between the Central Desert and Yuendumu populations and the previously reported Cape York and Kimberley aboriginal populations. A new DRB 1 allele, DRB 1 ∗ 1414, present at low frequency in the Central Desert population, was identified. DRB1 ∗ 1414 appears to be closely related to DRB 1 ∗ 1407 and is proposed to have arisen by intragenic recombination. A novel DR-DQ haplotype, DRB1 ∗ 1402-DRB3 ∗ 0101-DQA1 ∗ 0501-DQB1 ∗ 0402, was also identified. This haplotype may be ancestral to the DRB 1 ∗ 1409-DQB 1 ∗ 0402 haplotype present in these populations. The presence of alleles and haplotypes apparently confined to Australian aboriginal populations and differences in the distribution of these alleles in different populations suggests that evolution has occurred in the class II region in the period since colonization of Australia, an estimated 50,000 years ago. |
| Databáze: | OpenAIRE |
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