Impact of dietary propionate on fructose-induced changes in lipid metabolism, gut microbiota and short-chain fatty acids in mice
| Autor: | Gabriele I. Stangl, Frank Hirche, Christine Brütting, Milena Lara Bisch, Corinna Brandsch |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine 030209 endocrinology & metabolism Fructose Gut flora Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animals chemistry.chemical_classification 030109 nutrition & dietetics Bacteria biology Chemistry Lipid metabolism Fatty Acids Volatile Lipid Metabolism biology.organism_classification Antimicrobial Lipids Gut microbiome Gastrointestinal Microbiome Fatty Liver Mice Inbred C57BL Biochemistry Propionate Dysbiosis lipids (amino acids peptides and proteins) Propionates Food Science |
| Zdroj: | International Journal of Food Sciences and Nutrition. 72:160-173 |
| ISSN: | 1465-3478 0963-7486 |
| DOI: | 10.1080/09637486.2020.1773415 |
| Popis: | Propionate has antimicrobial activity and is suggested to influence lipid metabolism. Here, we investigated the effect of propionate on lipid metabolism and the gut microbiome in fructose-fed mice as a model of diet-induced steatosis and gut dysbiosis. Therefore, 48 male wild-type mice were fed isoenergetic diets with either 0% fructose (F-) or 40% fructose (F+) that contained 0% propionate (P-) or 1% propionate (P+) for 7 weeks. Mice that received the F+ diets developed fatty livers, had fewer small intestinal proteobacteria and colonic actinobacteria and were characterised by changes in bacterial genera (e.g. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|