Antimalarials may influence the risk of malignancy in systemic lupus erythematosus
| Autor: | Maider Garmendia, Amaia Ugarte, Agustin Martinez-Berriotxoa, Jose Ignacio Pijoan, Guillermo Ruiz-Irastorza, Ciriaco Aguirre, Maria-Victoria Egurbide |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Concise Report Adolescent Cyclophosphamide Immunology Antineoplastic Agents Azathioprine General Biochemistry Genetics and Molecular Biology Antimalarials Rheumatology Neoplasms Internal medicine Epidemiology medicine Humans Lupus Erythematosus Systemic Immunology and Allergy Risk factor Prospective cohort study Lupus erythematosus Proportional hazards model business.industry Cancer Middle Aged medicine.disease Surgery Antirheumatic Agents Drug Therapy Combination Female Epidemiologic Methods business Immunosuppressive Agents medicine.drug |
| Zdroj: | Annals of the Rheumatic Diseases. 66:815-817 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2006.067777 |
| Popis: | Recent studies suggest that antimalarials have antineoplastic properties.To investigate whether antimalarials decrease the risk of cancer in systemic lupus erythematosus (SLE).An observational prospective cohort study was carried out. 235 patients were included in the study at the time of diagnosis (American College of Rheumatology criteria). The end point was the diagnosis of cancer. Kaplan-Meier cancer-free survival curves for patients treated and not treated with antimalarials were compared. A Cox proportional hazards model was fitted, with cancer as the dependent variable. Age at diagnosis, gender, treatment with azathioprine, cyclophosphamide and methotrexate, smoking, Systemic Lupus International Collaborating Clinics (SLICC) Damage Index 6 months after diagnosis, year of diagnosis and treatment with antimalarials were entered as independent variables.209 (89%) patients were women. 233 (99%) patients were white. Mean (SD) age at diagnosis was 37 (16) years. Median (range) follow-up was 10 (1-31) years. 156 (66%) patients had ever received antimalarials. 2/156 (1.3%) ever-treated patients compared with 11/79 (13%) never-treated patients had cancer (p0.001). Cumulative cancer-free survival in treated and not treated patients was 0.98 and 0.73, respectively (p0.001). Adjusted hazard ratio for cancer among malaria drug users compared with non-users was 0.15 (95% CI 0.02 to 0.99).This study launches the hypothesis of a protective action of antimalarials against cancer in patients with SLE. This effect should be confirmed in larger multicentre studies. |
| Databáze: | OpenAIRE |
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