A randomized crossover study comparing the efficacy and tolerability of a novel once-daily morphine preparation (MXL® capsules) with MST Continus® tablets in cancer patients with severe pain
| Autor: | T. O'Brien, AJ Miller, CJ McDonald, PG Mortimer |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Randomization
Palliative care medicine.medical_treatment Pain Capsules Drug Administration Schedule Dosage form 03 medical and health sciences 0302 clinical medicine Double-Blind Method 030502 gerontology Neoplasms Humans Medicine Pain Measurement Chemotherapy Cross-Over Studies Morphine business.industry Palliative Care Cancer General Medicine Middle Aged medicine.disease Crossover study Analgesics Opioid Treatment Outcome Anesthesiology and Pain Medicine Tolerability Patient Satisfaction Delayed-Action Preparations 030220 oncology & carcinogenesis Anesthesia 0305 other medical science business medicine.drug |
| Zdroj: | Palliative Medicine. 11:475-482 |
| ISSN: | 1477-030X 0269-2163 |
| DOI: | 10.1177/026921639701100608 |
| Popis: | The efficacy, tolerability and 24-h duration of action of MXL® capsules, a novel once-daily morphine preparation, were compared with twice-daily morphine tablets (MST Continus® tablets) in patients with severe cancer pain. Eighty-five patients were recruited to this randomized, double-blind, double-dummy, crossover study. There was no significant difference between the two treatment groups in the number of occasions that escape medication was required, the pain scores at each of three time points throughout the day, and the number of nights woken due to pain. Both preparations were well tolerated with no significant difference in the number or severity of reported symptoms and side-effects. Sixteen patients withdrew from the study, of whom 13 withdrew for nontreatment-related reasons. There was no difference between the preparations in terms of expressed treatment preference. MXL capsules were shown to provide effective analgesia over the 24-h dosing interval which was comparable to that of MST Continus tablets administered twice daily. |
| Databáze: | OpenAIRE |
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