MOESM3 of Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Autor: Lefley, Diane, Howard, Faith, Arshad, Fawaz, Bradbury, Steven, Brown, Hannah, Tulotta, Claudia, Eyre, Rachel, Alférez, Denis, J. Wilkinson, Holen, Ingunn, Clarke, Robert, Ottewell, Penelope
Rok vydání: 2019
DOI: 10.6084/m9.figshare.11300081.v1
Popis: Additional file 3: Figure S3. Alterations in molecular pathways associated with bone metastasis. Heat map showing primary molecular pathways altered in MDA-MB-231 cells that have metastasised to human bone implants compared with the corresponding mammary tumours as assessed on whole genome Affymetrix arrays, analysed using DAVID (A). The number of genes altered between primary tumours that metastasised to bone compared with those that did not and the number of genes that changes between met static and non-met static primary tumours and bone metastases are shown in B. Panel C, shows the genetic pathways altered between primary tumours that metastasised to bone and metastatic deposits isolated from human bone implants.
Databáze: OpenAIRE