Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau
| Autor: | Indu Ayappa, N Bagchi, Ram A. Sharma, Eva Petkova, Zhe Chen, Kulkarni Prathamesh, Andrew W Varga, Ankit Parekh, Bianca Cavedoni, Korey Kam, Anna E Mullins, Andreia G. Andrade, B. Castillo, Omonigho M Bubu, Henrik Zetterberg, Nicholas J. Chua, Ricardo S. Osorio, Mony J. de Leon, David M. Rapoport, Nadia Gosselin, Lisa Mosconi, Monica Lewin, Lidia Glodzik, M D Miller, Kaj Blennow |
|---|---|
| Přispěvatelé: | Université de Montréal. Faculté des arts et des sciences. Département de psychologie |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Neurology Polysomnography Sleep spindle tau Proteins lcsh:Geriatrics Non-rapid eye movement sleep lcsh:RC346-429 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Alzheimer Disease Neuroplasticity mental disorders medicine Humans Cognitive decline Molecular Biology lcsh:Neurology. Diseases of the nervous system Aged Aged 80 and over Amyloid beta-Peptides medicine.diagnostic_test business.industry Actigraphy Middle Aged Healthy Volunteers Peptide Fragments lcsh:RC952-954.6 030104 developmental biology Memory consolidation Female Neurology (clinical) business Sleep Neuroscience 030217 neurology & neurosurgery Biomarkers Research Article |
| Zdroj: | Molecular Neurodegeneration Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-12 (2019) |
| ISSN: | 1750-1326 |
| Popis: | Background Based on associations between sleep spindles, cognition, and sleep-dependent memory processing, here we evaluated potential relationships between levels of CSF Aβ42, P-tau, and T-tau with sleep spindle density and other biophysical properties of sleep spindles in a sample of cognitively normal elderly individuals. Methods One-night in-lab nocturnal polysomnography (NPSG) and morning to early afternoon CSF collection were performed to measure CSF Aβ42, P-tau and T-tau. Seven days of actigraphy were collected to assess habitual total sleep time. Results Spindle density during NREM stage 2 (N2) sleep was negatively correlated with CSF Aβ42, P-tau and T-tau. From the three, CSF T-tau was the most significantly associated with spindle density, after adjusting for age, sex and ApoE4. Spindle duration, count and fast spindle density were also negatively correlated with T-tau levels. Sleep duration and other measures of sleep quality were not correlated with spindle characteristics and did not modify the associations between sleep spindle characteristics and the CSF biomarkers of AD. Conclusions Reduced spindles during N2 sleep may represent an early dysfunction related to tau, possibly reflecting axonal damage or altered neuronal tau secretion, rendering it a potentially novel biomarker for early neuronal dysfunction. Given their putative role in memory consolidation and neuroplasticity, sleep spindles may represent a mechanism by which tau impairs memory consolidation, as well as a possible target for therapeutic interventions in cognitive decline. Electronic supplementary material The online version of this article (10.1186/s13024-019-0309-5) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink