A case of refractory pouchitis complicated by cytomegalovirus infection requiring administration of ganciclovir and infliximab
| Autor: | Noriaki Orita, Michiko Nishino, Takuya Komura, Masahiro Yanagi, Masashi Nishikawa, Shuichi Kaneko, Atsuhiro Kawashima, Masashi Unoura, Takatoshi Yoshio, Takashi Kagaya |
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| Rok vydání: | 2020 |
| Předmět: |
Ganciclovir
Adult medicine.medical_specialty Congenital cytomegalovirus infection Pouchitis Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans business.industry Proctocolectomy Restorative virus diseases General Medicine Hepatology medicine.disease Ulcerative colitis Infliximab 030220 oncology & carcinogenesis Cytomegalovirus Infections 030211 gastroenterology & hepatology Colitis Ulcerative Female Pouch business Complication medicine.drug |
| Zdroj: | Clinical journal of gastroenterology. 14(1) |
| ISSN: | 1865-7265 |
| Popis: | Pouchitis is a frequent complication of surgical treatment of ulcerative colitis (UC), and is typically treated using antimicrobials. If pouchitis is refractory to antimicrobials, screening for complications, such as cytomegalovirus (CMV) infection, is necessary. However, the optimal approach to management of pouchitis complicated by CMV infection is unclear. We report the case of a 41-year-old female patient with UC presenting with pouchitis associated with CMV infection; she had received subtotal colectomy/ileal pouch anal anastomosis (IPAA). She was admitted to hospital with persistent fever, epigastric discomfort, and watery diarrhea despite receiving antibiotics. Laboratory findings showed inflammation and reactivation of CMV infection accompanied by liver injury. The endoscopic findings showed inflammation of the pouch and ileal mucosa on the oral side with extensive and deep punched-out ulcers. Immunohistological staining of biopsy specimens from an ulcerated lesion demonstrated CMV infection. Therefore, we diagnosed the patient with pouchitis complicated by CMV infection. The patient was treated with ganciclovir and infliximab, which resolved her symptoms and led to the disappearance of CMV-positive cells. There has been no recurrence of pouchitis. CMV infection should be considered in patients with UC who develop refractory pouchitis. |
| Databáze: | OpenAIRE |
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