Severe Respiratory Distress Following Sodium Oleate Ingestion
| Autor: | Akitsugu Kohama, Chiiho Fujii, Atsuhiro Fukuda, Keisuke Kumada, Tetsu Okumura, Ryozo Kobayashi, Kouichiro Suzuki |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Health Toxicology and Mutagenesis Anti-Inflammatory Agents Penicillins Lung injury Toxicology Methylprednisolone Systemic circulation High-Frequency Jet Ventilation Positive-Pressure Respiration Humans Medicine Ingestion Lung Respiratory Distress Syndrome Cefotiam Respiratory distress business.industry Delayed onset Combined Modality Therapy Cephalosporins Jet ventilation Treatment Outcome medicine.anatomical_structure Anesthesia Sodium oleate Ampicillin Female business Oleic Acid |
| Zdroj: | Journal of Toxicology: Clinical Toxicology. 36:587-589 |
| ISSN: | 0731-3810 |
| Popis: | Case Report: Oleic acid and oleate are pulmonary toxins used to create laboratory models of acute respiratory distress syndrome, but there is little information on human toxicity. We report the intentional ingestion of 50 mL sodium oleate 20% by a 22-year-old woman with no symptoms for the first 2 days after ingestion. Her respiratory status deteriorated rapidly on day 3 progressing to acute respiratory distress syndrome (Pao2/Fio2 < 100 nun Hg) on day 4. Treatment with high-dose steroids and intensive respiratory support including high-frequency jet ventilation were associated with gradual but complete recovery by day 39. The delayed onset of symptoms suggested that the lung injury was due to the systemic circulation of oleate to the lungs rather than to direct aspiration. In oral poisoning by sodium oleate, the lung is the first and most lethally affected target organ in humans. This case demonstrates that ingestion of a relatively small amount of sodium oleate can cause delayed, progressively s... |
| Databáze: | OpenAIRE |
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