Meta-Analysis Reveals the Association Between Male Occupational Exposure to Solvents and Impairment of Semen Parameters
| Autor: | Virginie Villes, I. Sari-Minodier, Anderson Loundou, Oana Ianos, Marie-Pascale Lehucher-Michel, Jeanne Perrin |
|---|---|
| Přispěvatelé: | Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), Centre Clinico-Biologique d’Assistance Médicale à la Procréation - CECOS [Hôpital de la Conception - APHM], Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Service de Médecine et Santé au Travail - AP-HM - La Timone, Epidémiologie et Sciences Sociales Appliquées à l'Innovation Médicale, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Unité d'Aide Méthodologique, Assistance Publique - Hôpitaux de Marseille (APHM)-CHU Marseille |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Carbon disulfide Physiology Ejaculate volume Semen Aromatic hydrocarbons [SDV.CAN]Life Sciences [q-bio]/Cancer [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Occupational Exposure Nerchlorethylene Humans Medicine 030212 general & internal medicine Glycol ethers [SDV.BDD.GAM]Life Sciences [q-bio]/Development Biology/Gametogenesis [SDV.EE.SANT]Life Sciences [q-bio]/Ecology environment/Health 030219 obstetrics & reproductive medicine Sperm Count business.industry Public Health Environmental and Occupational Health Sperm [SDE.ES]Environmental Sciences/Environmental and Society 3. Good health Semen Analysis N-dimethylformamide chemistry Male fertility Strictly standardized mean difference Meta-analysis Solvents Occupational exposure [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology Solvent exposure business |
| Zdroj: | Journal of Occupational and Environmental Medicine Journal of Occupational and Environmental Medicine, Lippincott, Williams & Wilkins, 2018, 60 (10), pp.e533-e542. ⟨10.1097/JOM.0000000000001422⟩ Journal of Occupational and Environmental Medicine, 2018, 60 (10), pp.e533-e542. ⟨10.1097/JOM.0000000000001422⟩ |
| ISSN: | 1076-2752 |
| DOI: | 10.1097/JOM.0000000000001422⟩ |
| Popis: | International audience; Objectives: Solvent exposure is among the most common occupational exposures to chemical toxicants; data about the impact of such exposure on semen parameters are contradictory. We conducted the first meta-analysis to evaluate the risk of alteration in semen parameters related to occupational exposure to solvents. Methods: From the PubMed database, we selected studies analyzing the semen of subjects occupationally exposed to solvents, compared with unexposed controls. The meta-analysis was performed on the various semen parameters analyzed in both populations. Results: Seven studies were included in the study. The meta-analysis revealed a significant decrease in ejaculate volume [standardized mean difference (SMD) ¼ À0.35 (À0.63 to À0.07)] and sperm concentration [SMD ¼ À0.36 (À0.64 to À0.08)] in workers exposed to solvents compared with unexposed controls. Conclusion: Our results highlight the importance of preventing reprotoxic risks to male fertility in the workplace. |
| Databáze: | OpenAIRE |
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