Alpha-Melanocyte-Stimulating Hormone is Elevated in Hypothalamic Obesity Associated with Childhood Craniopharyngioma
| Autor: | Ayfer Alikasifoglu, Nazli Gonc, Nurgun Kandemir, Alev Ozon, Dicle Canoruc Emet |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Leptin
Male medicine.medical_specialty Pediatric Obesity Adolescent Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Neuropeptide 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound Craniopharyngioma 0302 clinical medicine Endocrinology Internal medicine medicine Humans 030212 general & internal medicine Child Nutrition and Dietetics business.industry Brain-Derived Neurotrophic Factor Childhood Craniopharyngioma medicine.disease Obesity alpha-Melanocyte-stimulating hormone chemistry alpha-MSH Female Melanocortin business hormones hormone substitutes and hormone antagonists Biomarkers Hypothalamic Diseases Hormone |
| Zdroj: | Obesity (Silver Spring, Md.)References. 29(2) |
| ISSN: | 1930-739X |
| Popis: | OBJECTIVE The purpose of this study was to investigate the peripheral concentrations of leptin and neuropeptides taking part in the melanocortin pathway in hypothalamic obesity (HO) associated with craniopharyngioma (CP) and to find a peripheral marker for diagnosis. METHODS Thirty-one patients (52% girls; median age 16 years) with CP were enrolled in the study group. They were grouped as CP with obesity (CPobesity , n = 17) and CP without obesity (CPnonobesity , n = 14). Two control groups without CP consisted of 27 children with obesity (OC) (55% girls; median age 13.8 years) and 25 children without obesity (normal control [NC]) (72% girls; median age 14.5 years). Obesity was defined as BMI percentile ≥ 95%. Fasting serum concentrations of leptin, brain-derived neurotrophic factor (BDNF), and alpha-melanocyte-stimulating hormone (α-MSH) were measured in the groups. RESULTS Leptin and BDNF concentrations were correlated with BMI SD score (SDS) in controls (OC + NC) and CP. However, there was no correlation between α-MSH and BMI-SDS in CP or control groups. After adjusting for age, sex, and BMI-SDS, α-MSH was found to be significantly higher in CPobesity than in other groups, whereas leptin and BDNF were comparable among the four groups. CONCLUSIONS Serum BDNF, just like leptin, increased with BMI, regardless of hypothalamic damage. On the contrary, α-MSH concentration was significantly high in HO, designating a potential biomarker for HO in CP. |
| Databáze: | OpenAIRE |
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