Evolution of allograft fibrosis and function in kidney transplant recipients: a retrospective analysis of stable patients under CNI and mTORi
| Autor: | Claudia Sommerer, Rüdiger Waldherr, Luis E. Becker, Marie-Luise Gross-Weissmann, Martin Zeier, Bernhard Weritz, Xue Yi |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Pathology medicine.medical_specialty Biopsy Calcineurin Inhibitors Urology Kidney Kidney transplant Transforming Growth Factor beta1 Fibrosis Complement C4b Retrospective analysis Humans Medicine Kidney transplantation Retrospective Studies Platelet-Derived Growth Factor Transplantation Everolimus medicine.diagnostic_test business.industry TOR Serine-Threonine Kinases Incidence (epidemiology) Middle Aged Allografts Hypoxia-Inducible Factor 1 alpha Subunit medicine.disease Immunohistochemistry Kidney Transplantation Peptide Fragments Calcineurin Disease Progression Kidney Failure Chronic Female Fibroblast Growth Factor 2 business Immunosuppressive Agents medicine.drug |
| Zdroj: | Transplant International. 28:553-564 |
| ISSN: | 0934-0874 |
| DOI: | 10.1111/tri.12529 |
| Popis: | Summary Histological evaluations of renal allograft biopsies are essential for diagnosis, but still show a low predictive value for long-term allograft function. One limitation relies on the fact that the analysis is usually based on a single biopsy sample, and therefore, no dynamic changes are considered. Using two distinct approaches, we evaluated the evolution of fibrosis and related markers in 36 stable kidney transplant patients under calcineurin inhibitor therapy with two indication biopsies each, prior and at least 6 months after substitution by mTORi (N = 18), or maintenance on CNI (N = 18). In the method comparison, both Banff chronicity score and the digitally assessed fibrosis were correlated with allograft function at biopsy (r = −0.36 and r = −0.72, P = 0.002 and P |
| Databáze: | OpenAIRE |
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