Rapid spread of double East- and West-African kdr mutations in wild Anopheles coluzzi from Côte d’Ivoire
| Autor: | France-Paraudie Kouadio Affoue, Benjamin G. Koudou, Prisca Bédjou N'Dri, Chouaibou S. Mouhamadou, Behi K. Fodjo, Christabelle Gba Sadia |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Veterinary medicine biology 030231 tropical medicine Indoor residual spraying Anopheles Medicine (miscellaneous) Knockdown resistance Cote d ivoire biology.organism_classification medicine.disease General Biochemistry Genetics and Molecular Biology 3. Good health 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Insecticide resistance parasitic diseases Genotype Threatened species medicine Malaria |
| Zdroj: | Wellcome Open Research. 4:31 |
| ISSN: | 2398-502X |
| DOI: | 10.12688/wellcomeopenres.15105.1 |
| Popis: | Malaria morbidity and mortality rates in Sub-Saharan Africa are increasing. The scale-up of long-lasting insecticidal nets and indoor residual spraying have been the major contributors to the decrease of malaria burden. These tools are now threatened by insecticide resistance in malaria vectors, which is spreading dramatically. After two different real-time polymerase chain reaction molecular characterizations carried out on 70 mosquitoes sampled in the locality of Elibou in southern Côte d’Ivoire, results revealed that 9 mosquitoes from Anopheles coluzzi harbored the double East- and West-African knockdown resistance mutations. In the previous year, only 1 mosquito out of 150 sampled from 10 regions of the country had the same genotype. These results show the rapid spread of insecticide resistance in malaria vectors and highlight the urgent need to diversify the methods of vector control in order to avoid the failure of insecticide-based vector control tools which may favor malaria fatalities. |
| Databáze: | OpenAIRE |
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