Evaluation of rat major celluler prion protein (PrPC) for early diagnosis in experimental rat brain trauma model
| Autor: | Halil Dogan, Alev Kural, Sezgin Sarikaya, Sebnem Tekin Neijmann, Nurten Sever, Aysun Toker |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
030506 rehabilitation
Pathology medicine.medical_specialty Traumatic brain injury Positive correlation Sensitivity and Specificity Prion Proteins 03 medical and health sciences 0302 clinical medicine Brain Injuries Traumatic Animals Medicine In patient Prion protein Pathological business.industry Prognosis medicine.disease Rat brain Rats nervous system diseases Disease Models Animal Early Diagnosis Anesthesiology and Pain Medicine Blunt trauma Emergency Medicine Biomarker (medicine) Surgery 0305 other medical science business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Turkish Journal of Trauma and Emergency Surgery. |
| ISSN: | 1306-696X |
| DOI: | 10.5505/tjtes.2018.46923 |
| Popis: | BACKGROUND Although traumatic brain injury (TBI) is an important problem, there has been no widespread utilization of neuro-biomarkers to aid the diagnosis of TBI. This study was conducted to evaluate serum S100B and prion protein (PrPC) levels in rats with TBI. METHODS In this study, 15 albino rats were categorized into three groups as follows: sham-operated (1), control (6) and trauma (8) groups. The TBI model was based on the modified free falling model. S100B, PrPC levels were measured using ELISA. Brain specimens were obtained for the pathological examination. RESULTS Serum S100B and PrPC levels were found to increase in T group at both 2h and 24h after trauma (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|