Gamma-aminobutyric acid ameliorates gamma rays-induced oxidative stress in the small intestine of rats
| Autor: | Manal A. Badawi, Noaman A. Eltahawy, Amr Mahmoud Abd El-Hady, Hanan Gewefel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant medicine.medical_treatment medicine.disease_cause gamma-Aminobutyric acid 03 medical and health sciences chemistry.chemical_compound GABA 0302 clinical medicine Internal medicine lcsh:Zoology medicine lcsh:QL1-991 chemistry.chemical_classification Lamina propria biology Glutathione peroxidase Small intestine Malondialdehyde Paneth cells 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Catalase Gamma radiation Oxidative stress 030220 oncology & carcinogenesis biology.protein medicine.drug |
| Zdroj: | Journal of Basic and Applied Zoology, Vol 78, Iss 1, Pp 1-9 (2017) |
| Popis: | Background The current study aimed to evaluate the role of gamma-amino butyric acid (GABA) in modulating histopathological and biochemical disturbances in the rat’s small intestine following gamma radiation exposure. Results The results showed that whole body gamma irradiation (6 Gy) of rats induced mucosal damage, hemorrhage, increased cellularity of the lamina propria layer with areas of complete ulcerations. Histopathological changes were associated with a significant increase in malondialdehyde (MDA) and advanced oxidation protein products (AOPPs). In parallel, a significant decrease in catalase (CAT) and glutathione peroxidase (GSH-Px) activities was demonstrated. Administration of GABA (200 mg/kg body weight GABA daily via gastric gavage for three consecutive weeks) after irradiation of rats has significantly improved the oxidant/antioxidant status which was associated with regeneration of the small intestinal cell structure. Conclusion Gastric administration of GABA was found to offer an advantageous treatment against gamma irradiation-induced small intestine oxidative stress in rats, probably by utilizing ameliorative effects via its antioxidant and free radical-scavenging activities. Its mechanisms need to be further investigated. |
| Databáze: | OpenAIRE |
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