The ???159C/T Polymorphism in the Promoter Region of the CD14 Gene Is Associated With Advanced Liver Disease and Higher Serum Levels of Acute-Phase Proteins in Heavy Drinkers
| Autor: | Arturo Gonzalez-Quintela, Celsa Quinteiro, Jose-Antonio Torre, Carmen Vidal, Luis-Fernando Perez, Francisco Gude, Joaquin Campos |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcoholic liver disease Cirrhosis CD14 Lipopolysaccharide Receptors Immunoglobulins Medicine (miscellaneous) Toxicology Gastroenterology Liver disease Liver Function Tests Liver Cirrhosis Alcoholic Risk Factors Internal medicine Genotype medicine Humans Promoter Regions Genetic Aged Membrane Glycoproteins Polymorphism Genetic biology Acute-phase protein Odds ratio Middle Aged medicine.disease Psychiatry and Mental health C-Reactive Protein Spain Hepatic Encephalopathy Immunology biology.protein Female Antibody Carrier Proteins Acute-Phase Proteins |
| Zdroj: | Alcoholism: Clinical & Experimental Research. 29:1206-1213 |
| ISSN: | 0145-6008 |
| DOI: | 10.1097/01.alc.0000171977.25531.7a |
| Popis: | Background: Innate inflammatory responses to endotoxin (lipopolysaccharide) contribute to the development of alcoholic liver disease (ALD). A single-nucleotide polymorphism (−159C/T) in the promoter region of the gene coding for CD14 (a lipopolysaccharide receptor) could be associated with the development of ALD. We sought too investigate the relationship between the CD14/−159C/T polymorphism and advanced ALD and acute-phase protein levels in heavy drinkers. Methods: A total of 138 heavy drinkers consecutively admitted to an Internal Medicine department were genotyped for the CD14/−159C/T polymorphism. Serum samples were analyzed for lipopolysaccharide-binding protein (LBP), soluble CD14 (sCD14), C-reactive protein (CRP), and immunoglobulin (Ig) A, IgG, and IgM. Patients with ascites or liver encephalopathy (n= 35) were classified as having advanced ALD. Results: After adjusting for potential confounding variables, the CD14/-159TT genotype was positively associated with advanced ALD (odds ratio, 2.99; 95% confidence interval, 1.09–8.24, p= 0.03) and serum LBP (p= 0.01) and sCD14 (p= 0.04) levels. The CD14/−159C/T polymorphism was not associated with serum levels of CRP, IgA, IgG, or IgM. Conclusions: Our results support the notion that CD14/−159TT homozygous heavy drinkers have higher levels of the LPS-binding acute-phase proteins (LBP and sCD14) than do carriers of the CD14/−159C allele. Also, the CD14/−159TT genotype may be a risk factor for advanced ALD. |
| Databáze: | OpenAIRE |
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