Mianserin treatment of patients with psychosis induced by antiparkinsonian drugs
| Autor: | K. Ikeguchi, A. Kuroda |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Psychosis Parkinson's disease Trihexyphenidyl Administration Oral Mianserin Drug Administration Schedule Psychoses Substance-Induced Antiparkinson Agents medicine Humans Pharmacology (medical) Biological Psychiatry Aged Aged 80 and over Neurologic Examination Psychiatric Status Rating Scales Dose-Response Relationship Drug Parkinsonism Amantadine Parkinson Disease General Medicine medicine.disease Psychiatry and Mental health Carbidopa Anesthesia Delirium Female medicine.symptom Psychology medicine.drug |
| Zdroj: | European Archives of Psychiatry and Clinical Neuroscience. 244:320-324 |
| ISSN: | 1433-8491 0940-1334 |
| DOI: | 10.1007/bf02190411 |
| Popis: | We evaluated the effects of mianserin, a relatively selective 5-HT2 receptor antagonist, on symptoms related to drug-induced psychosis in patients with Parkinson's disease (PD). A total of 12 patients with PD who had developed drug-induced psychosis showed delirium (DSM-III-R criteria; n = 10) and pure visual hallucinations (n = 2). The antiparkinsonian drugs involved in the drug-induced psychosis were L-DOPA/carbidopa, bromocriptine, trihexyphenidyl, and amantadine. They received mianserin (mean 36.7 mg, range 20-60 mg) given orally for 8 weeks. Complete relief or marked improvement in psychotic symptoms was noted in 8 patients, moderate improvement in 2 patients, and no effect in 2 patients. The parkinsonian disability also decreased slightly in 8 patients. These results suggest that serotonin antagonism at 5-HT2 receptors may not only play an important role in the treatment of drug-induced psychosis in PD, but may also ameliorate the symptoms of parkinsonism. |
| Databáze: | OpenAIRE |
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