Evaluation of Prostate-Specific Antigen in Untreated Prostatic Carcinoma
| Autor: | Oosterom R, Schröder Fh, J F Bogdanowicz |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Urology Microgram Acid Phosphatase Prostatic Hyperplasia urologic and male genital diseases Antigen Antigens Neoplasm Prostate Internal medicine Biomarkers Tumor medicine Carcinoma Humans Aged Aged 80 and over business.industry Prostatic Neoplasms Cancer Middle Aged Prostate-Specific Antigen Hyperplasia medicine.disease Prostate-specific antigen medicine.anatomical_structure Endocrinology Prostatic acid phosphatase business |
| Zdroj: | European Urology. 16:253-257 |
| ISSN: | 1873-7560 0302-2838 |
| DOI: | 10.1159/000471586 |
| Popis: | A study was performed on 290 men to compare the level of serum prostate-specific antigen (PSA) in controls, patients with benign prostatic hyperplasia (BPH) and patients with prostatic cancer. The upper limit of normal was 5.0 micrograms/l as determined in 110 elderly hospitalized males (mean age 62 years) without urological complaints. Of the 106 patients with BPH, 33% had raised values above 5.0 micrograms/l. Values above 10 micrograms/l were found in 18 BPH patients. A positive correlation was found between prostate volume (grams of tissue removed during transurethral resection) and preoperative PSA levels (r = 0.55, n = 106, p less than 0.001). PSA levels above 10 micrograms/l were found in 4% of BPH patients with a prostate volume of less than 20 g (n = 54), in contrast with 45% of patients with a prostate volume above 40 g (n = 20). The sensitivity of this PSA assay (cutoff level 10 micrograms/l) as established in 74 prostate carcinoma patients was 31% for category T0 (n = 13), 56% for category T1-2 (n = 16), 75% for category T3-4 (n = 20) and 100% for category M1 or N1-4 (n = 25). In an earlier study prostatic acid phosphatase (PAP) was measured in these same samples. PSA appeared to be much more sensitive than PAP. Seventeen of the 74 prostatic carcinoma patients (23%) had normal PAP levels but their PSA values were raised above 10 micrograms/l, while in only 2 patients an increased PAP level was combined with a normal PSA.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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