Toxoplasma gondii-specific IgG avidity testing in pregnant women
| Autor: | Isabelle Villena, Laetitia Maria Kortbeek, Hervé Pelloux, Peter L. Chiodini, Birgitta Evengård, Cécile Garnaud, Eskild Petersen, Marie-Pierre Brenier-Pinchart, Hélène Fricker-Hidalgo, Carmen Costache, Małgorzata Paul, Florence Robert-Gangneux, Valeria Meroni, Míriam J. Álvarez-Martínez, Edward Guy |
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| Přispěvatelé: | CHU Grenoble, Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Umeå University, University of Barcelona, Aarhus University [Aarhus], National Institute for Public Health and the Environment [Bilthoven] (RIVM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle (ESCAPE), Université de Reims Champagne-Ardenne (URCA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Iuliu Hatieganu University of Medicine & Pharmacy, Poznan University of Medical Sciences [Poland] (PUMS), London School of Hygiene and Tropical Medicine (LSHTM), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) [SDV]Life Sciences [q-bio] 030106 microbiology Antibody Affinity Avidity testing Toxoplasma gondii chemical and pharmacologic phenomena Serology 03 medical and health sciences 0302 clinical medicine Pregnancy parasitic diseases Medicine Humans Avidity 030212 general & internal medicine Congenital toxoplasmosis biology business.industry General Medicine Specific igg Igg avidity biology.organism_classification medicine.disease Toxoplasmosis 3. Good health Infectious Diseases Immunoglobulin G Pregnancy Complications Parasitic Immunology Female business Toxoplasma |
| Zdroj: | Clinical Microbiology and Infection Clinical Microbiology and Infection, 2020, 26 (9), pp.1155-1160. ⟨10.1016/j.cmi.2020.04.014⟩ under the auspices of the ESGCP of ESCMID 2020, ' Toxoplasma gondii-specific IgG avidity testing in pregnant women ', Clinical Microbiology and Infection, vol. 26, no. 9, pp. 1155-1160 . https://doi.org/10.1016/j.cmi.2020.04.014 Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2020, 26 (9), pp.1155-1160. ⟨10.1016/j.cmi.2020.04.014⟩ |
| ISSN: | 1469-0691 1198-743X |
| DOI: | 10.1016/j.cmi.2020.04.014⟩ |
| Popis: | International audience; Background - The parasite Toxoplasma gondii can cause congenital toxoplasmosis following primary infection in a pregnant woman. It is therefore important to distinguish between recent and past infection when both T. gondii-specific IgM and IgG are detected in a single serum in pregnant women. Toxoplasma gondii-specific IgG avidity testing is an essential tool to help to date the infection. However, interpretation of its results can be complex. Objectives - To review the benefits and limitations of T. gondii-specific avidity testing in pregnant women, to help practitioners to interpret the results and adapt the patient management. Sources - PubMed search with the keywords avidity, toxoplasmosis and Toxoplasma gondii for articles published from 1989 to 2019. Content - Toxoplasma gondii-specific IgG avidity testing remains a key tool for dating a T. gondii infection in immunocompetent pregnant women. Several commercial assays are available and display comparable performances. A high avidity result obtained on a first-trimester serum sample is indicative of a past infection, which occurred before pregnancy. To date, a low avidity result must still be considered as non-informative to date the infection, although some authors suggest that very low avidity results are highly suggestive of recent infections depending on the assay. Interpretation of low or grey zone avidity results on a first-trimester serum sample, as well as any avidity result on a second-trimester or third-trimester serum sample, is more complex and requires recourse to expert toxoplasmosis laboratories. Implications - Although used for about 30 years, T. gondii-specific avidity testing has scarcely evolved. The same difficulties in interpretation have persisted over the years. Some authors have proposed additional thresholds to exclude an infection of |
| Databáze: | OpenAIRE |
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