Pregnancy induced hypertension and outcomes in early and moderate preterm infants
| Autor: | Jie Lin, Kun Liang, Ling Liu, Cheng-Qiu Lu, Jin-Hua Huang, Zhi Zheng, Qing-Hua Zhong, Zhan-Kui Li, Lin Yuan, Chao Chen, Hui Wu, Li-Li Ping, Yi Sun, Jian-Guo Zhou, Qin Lyu, Li-Ping Xu |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Neonatal respiratory distress syndrome medicine.medical_specialty China Birth weight Intrauterine growth restriction Gestational Age Infant Premature Diseases Cohort Studies 03 medical and health sciences 0302 clinical medicine Pregnancy Internal Medicine medicine Birth Weight Humans 030212 general & internal medicine Prospective Studies 030219 obstetrics & reproductive medicine Fetal Growth Retardation business.industry Obstetrics Infant Newborn Pregnancy Outcome Obstetrics and Gynecology Gestational age Retinopathy of prematurity Hypertension Pregnancy-Induced medicine.disease Bronchopulmonary dysplasia Necrotizing enterocolitis Female business Infant Premature Cohort study |
| Zdroj: | Pregnancy hypertension. 14 |
| ISSN: | 2210-7797 |
| Popis: | To identify the effect of pregnancy induced hypertension on neonatal outcomes in early and moderate preterm infants of gestational age less than 34 weeks.Prospectively collected data in 773 premature deliveries less than 34 weeks from 10 centers in China between July 2014 and July 2016 were analyzed in this cohort study. Univariate and Multivariate regression analyses were conducted to exam the effect of pregnancy induced hypertension on neonatal outcomes, including mortality to discharge, intrauterine growth restriction, severe brain injury, neonatal respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, early onset of sepsis and retinopathy of prematurity.The incidence of PIH in this cohort was 18.4%. Women with PIH tended to have a higher cesarean delivery rate (78.2% vs 40.9%, P 0.001). More tocolytics and magnesium sulfate were used in PIH women (72.5% vs 48.7%, P 0.001; 59.2% vs 34.7%, P 0.001). Mean birth weight was lower in infants of PIH mothers than infants of non-PIH mothers (1522.1 ± 348.8 g vs 1683.4 ± 345.3, P 0.001). In multivariate regression models, PIH was associated with increased risk of IUGR (OR 8.402; 95% CI 4.350-16.227) and lower odds of NRDS (OR 0.526; 95% CI 0.332-0.853).Preterm infants less than 34 weeks born to PIH women had a higher risk of intrauterine growth restriction and lower birth weight. PIH warrants more intensive interventions to prevent relevant infant morbidities. |
| Databáze: | OpenAIRE |
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