The role of renal damage on cardiac remodeling in patients with diabetic nephropathy
| Autor: | Hou-Yong Dai, Hong-Lang Xie, Yi-De Zhang, Zhihong Liu, Qiao-Lin Zhou |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart Ventricles Diastole Renal function Cardiomegaly Doppler echocardiography Severity of Illness Index Diabetic nephropathy Internal medicine medicine Humans Diabetic Nephropathies Interventricular septum Aged Retrospective Studies Aged 80 and over Kidney Ejection fraction Ventricular Remodeling medicine.diagnostic_test business.industry General Medicine Middle Aged Prognosis medicine.disease Echocardiography Doppler medicine.anatomical_structure Nephrology Ventricle Disease Progression cardiovascular system Cardiology Female business Follow-Up Studies |
| Zdroj: | Clinical Nephrology. 80:249-255 |
| ISSN: | 0301-0430 |
| DOI: | 10.5414/cn107875 |
| Popis: | Cardiovascular damage and diabetic nephropathy are major complications in patients with Type 2 diabetic nephropathy (T2DN); however, the role of renal damage on cardiac remodeling is not yet fully known.A retrospective research was conducted in 254 T2DN patients. All were divided into three groups according to urinary albumin excretion (UAE): the normoalbuminuria group (UAE30 mg/g, n = 18), the microalbuminuria group (UAE 30 - 300 mg/g, n = 99) and the macroalbuminuria group (UAE300 mg/g, n = 137). The parameters of cardiac remodeling, left atrial diameter (LAD), left ventricular diameter at the end of diastole (LVDd), interventricular septum (IVS), posterior wall of left ventricle (PWLV) and ejection fraction (EF), were determined by Doppler echocardiography. The effects of renal damage on cardiac remodeling were analyzed.Among the 254 patients, LAD and LVDd enlargement was found in 180 (70.86%) and 53 (20.86%) patients, respectively; 46 cases (18.11%) suffered from both LAD and LVDd enlargement. Compared with normal LAD/LVDd groups, creatinine clearance (Ccr) and hemoglobin (Hb) were significantly lower in the left atrial (LA) and left ventricular (LV) dilated groups. LAD was positively correlated with mesangial sclerosis, tubular-interstitial lesions, interstitial fibrosis, as well as tubular basement membrane thickness (r = 0.273, 0.208, 0.176, 0.155, p0.05, respectively). Moreover, in comparison to patients with LA enlargement, more severe renal damage was detected in patients with LV enlargement.There is a strong correlation between echocardiographic parameters and kidney lesions in patients with T2DN in China; the more severe the renal damage, the more severe the cardiac structural alteration. Renal damage contributes to cardiac remodeling, which may provide new insights into the pathogenesis of cardiovascular complications ,in diabetes mellitus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|