Synergistic Effects of SAM and Selenium Compounds on Proliferation, Migration and Adhesion of HeLa Cells
| Autor: | Yiqun Liu, Qin Wang, Jianxin Zhang, Feng Han, Yang Si, Qiu Yang, Licui Sun, Zhen-wu Huang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway S-Adenosylmethionine Cancer Research MAP Kinase Signaling System Uterine Cervical Neoplasms HeLa Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Movement Cell Adhesion Animals Humans Selenium Compounds Cell adhesion Protein kinase B Cell Proliferation Matrigel biology Cell growth Drug Synergism General Medicine biology.organism_classification Xenograft Model Antitumor Assays Molecular biology Gene Expression Regulation Neoplastic Methylselenocysteine 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis Female Signal transduction Proto-Oncogene Proteins c-akt HeLa Cells |
| Zdroj: | Anticancer Research. 37 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.11838 |
| Popis: | BACKGROUND/AIM To determine the antitumor activities and molecular mechanism of selenium compounds in HeLa cells. MATERIALS AND METHODS Western blotting was used to detect ERK and AKT activation in HeLa cells induced by selenium compounds selenomethionine (SeMet), methylselenocysteine (MeSeCys) and methylseleninic acids (MeSeA). Using MTT, wound-healing and Matrigel adhesion assays, the antitumor effects of SAM and selenium compounds were evaluated in HeLa cells. RESULTS MeSeA inhibited ERK and AKT signaling pathways and suppressed the proliferation (p |
| Databáze: | OpenAIRE |
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