Glioblastoma Multiforme, Diagnosis and Treatment; Recent Literature Review
| Autor: | Nicole Francis, P. M. Schaffer, Ron Batash, Noam Asna, Moshe Schaffer |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty medicine.medical_treatment Cell- and Tissue-Based Therapy Brain tumor Biochemistry 03 medical and health sciences 0302 clinical medicine Internal medicine Drug Discovery medicine Adjuvant therapy Humans Antineoplastic Agents Alkylating Survival rate Pharmacology Chemotherapy Brain Neoplasms business.industry Incidence (epidemiology) Organic Chemistry Antibodies Monoclonal Dendritic Cells Immunotherapy medicine.disease Combined Modality Therapy Surgery Radiation therapy Clinical trial Poliovirus 030104 developmental biology 030220 oncology & carcinogenesis Molecular Medicine Glioblastoma business |
| Zdroj: | Current Medicinal Chemistry. 24 |
| ISSN: | 0929-8673 |
| DOI: | 10.2174/0929867324666170516123206 |
| Popis: | Background Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, with an incidence of 3.19 cases per 100,000 person years and remarkably poor prognosis showing a 5-year survival rate of 4-5%, and only a 26-33% survival rate at 2 years in clinical trials. Objective In this paper, we review the different types of treatment modalities based on the relevant databases. Methods of diagnosis will be described briefly. Method Systemic compilation of the relevant literature. Results & conclusion Today's treatments cannot cure GBM patients but only extend their overall survival. The use of chemoradiation, immunotherapy, and radio sensitizers as an adjuvant therapy cannot reduce the high rates of recurrence within a few months after treatment. Radiotherapy will remain the backbone of the treatment but new treatment modalities must be developed. |
| Databáze: | OpenAIRE |
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