Genetic polymorphism in DGCR8 is associated with late onset of preeclampsia

Autor:	Yujing Zhang, Jun Lei, Dapeng Wang, Zuodong Li, Xin Huang
Rok vydání:	2019
Předmět:	0301 basic medicine Adult Male lcsh:Internal medicine medicine.medical_specialty lcsh:QH426-470 Genotype Case control study Late onset Single-nucleotide polymorphism 030105 genetics & heredity Lower risk Gastroenterology Polymorphism Single Nucleotide Preeclampsia DGCR8 03 medical and health sciences Young Adult Pre-Eclampsia Pregnancy Internal medicine Genetics medicine Genetic predisposition Genetic susceptibility Humans Genetic Predisposition to Disease MicroRNA machinery genes lcsh:RC31-1245 Genetics (clinical) Genetic Association Studies business.industry Haplotype Case-control study RNA-Binding Proteins medicine.disease lcsh:Genetics MicroRNAs 030104 developmental biology Logistic Models Haplotypes Case-Control Studies Female business Maternal Age Research Article
Zdroj:	BMC Medical Genetics BMC Medical Genetics, Vol 20, Iss 1, Pp 1-6 (2019)
ISSN:	1471-2350
Popis:	Background PE (preeclampsia) is a heterogeneous disorder with early onset PE (EOPE) and late onset PE (LOPE) subtypes. Associations between maternal miRNAs biosynthesis genes polymorphisms and risk of PE have been previously observed. However, the impact of polymorphisms in DGCR8 which is indispensable in miRNA maturing processing on the susceptibility to preeclampsia (PE) has not been elucidated yet. We, therefore, conducted a case-control study to evaluate the impact of polymorphisms in DGCR8 on the risk of EOPE and LOPE. Methods A total of 66 patients diagnosed with EOPE, 206 with LOPE and 330 healthy controls were recruited. Five SNPs in DGCR8 were genotyped including rs1558496, rs1640299, rs720012, rs720014, and rs9606241. Logistic regression was used to estimate the OR and the 95% CI for the associations. Results Increased risk of LOPE has been observed among patients with rs1640299 TG genotype (OR = 1.98 (95%CI: 1.38, 2.87), p = 2.32e-4) and rs720014 TC genotype (OR = 2.49 (95%CI: 1.72, 3.60), p = 1.40e-7). The DGCR8 rs1558496/ rs1640299/ rs720012/ rs720014/ rs9606241 haplotype T-G-A-C-A and T-G-A-C-G were associated with increased risk of LOPE (OR = 2.20 (95%CI: 1.49, 3.25), p = 5.90e-5, and 1.58 (95%CI: 1.06, 2.36), p = 0.024, respectively). And the haplotype T-T-G-T-A was associated with lower risk of LOPE (OR = 0.74 (95%CI: 0.58, 0.95), p = 0.018). These significant associations retained after false-positive discovery rate correction. However, none of the tested SNPs or haplotypes in DGCR8 gene is associated with risk of EOPE (p > 0.05). Conclusions Polymorphisms in DGCR8 might participate in the pathological process of preeclampsia. The rs1640299 T > G and rs720014 T > C polymorphisms are associated with late onset preeclampsia susceptibility. Electronic supplementary material The online version of this article (10.1186/s12881-019-0887-7) contains supplementary material, which is available to authorized users.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1936dcc37169cbd6e44256637600a1dc https://pubmed.ncbi.nlm.nih.gov/31484500 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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