Increased inflammatory Response in Patients With Dilated Cardiomyopathy Is Associated With Dyslipidemia: Effects of Statin Therapy
| Autor: | Constantinos J. Limas, Dimitrios Degiannis, Christos Kroupis, Zaharias-Alexandros Anyfantakis, Dennis V. Cokkinos, Panagiotis Iakovis |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cardiomyopathy
Dilated Male Simvastatin medicine.medical_specialty Diet therapy Cardiomyopathy Gastroenterology law.invention Randomized controlled trial law Internal medicine medicine Humans Prospective Studies cardiovascular diseases Prospective cohort study Dyslipidemias Inflammation business.industry Dilated cardiomyopathy Middle Aged medicine.disease Cardiology Increased inflammatory response Female Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business Dyslipidemia medicine.drug |
| Zdroj: | Angiology. 62:55-61 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/0003319710384396 |
| Popis: | Dilated cardiomyopathy (DCM) is associated with increased inflammatory response reflected among other markers in high-sensitivity C-reactive protein (hsCRP) and soluble interleukin-2 receptor (sIL-2R) levels. We examined prospectively 60 consecutive patients with DCM. Of them, 30 were dyslipidemic (group I) and 30 normolipidemic (group II). Group I patients were randomized to either simvastatin therapy (20 mg/day, group Ia, n = 15) or hypolipidemic diet therapy (group Ib, n = 15). Patients were re-evaluated 6 months later. High-sensitivity C-reactive protein and sIL-2R levels were significantly higher in group I compared with group II patients (19.5 ± 3.4 vs 3.03 ± 3.5 mg/L, P = .01, 1137 ± 441 vs 599 ± 235 pg/mL, P = .001, respectively). There was a significant correlation between sIL-2R and hsCRP levels in dyslipidemic patients but not in normolipidemic patients. Significant reduction of hsCRP and sIL-2R levels was observed only in group Ia patients. Patients with DCM having dyslipidemia have increased inflammatory response, which is reduced after 6 months of statin therapy. |
| Databáze: | OpenAIRE |
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