A Functional Virgin Olive Oil Enriched with Olive Oil and Thyme Phenolic Compounds Improves the Expression of Cholesterol Efflux-Related Genes: A Randomized, Crossover, Controlled Trial
| Autor: | Anna Pedret, Rosa Solà, Montserrat Fitó, Silvia Carrión, Marta Farràs, Marjon Kool, Sara Fernández-Castillejo, María Isabel Covas, Laura Rubió, Olga Castañer, Isaac Subirana, Álvaro Hernáez, Sara Arranz, Joan Carles Escolà-Gil, Daniel Muñoz-Aguayo, Maria-José Motilva, Gemma Blanchart, Ramon Estruch |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, European Commission, Generalitat de Catalunya, Escolà-Gil, Joan Carles [0000-0001-9021-2485], Rubió, Laura [0000-0001-8973-2942], Escolà-Gil, Joan Carles, Rubió, Laura |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Time Factors law.invention chemistry.chemical_compound transcriptomics Randomized controlled trial law HDL cholesterol Gene expression CYP27A1 Food science Cholesterol efflux Cross-Over Studies Nutrition and Dietetics Middle Aged Cholesterol Treatment Outcome Olive oil phenolic compounds olive oil phenolic compounds Food Fortified Functional virgin olive oil Female Efflux lcsh:Nutrition. Foods and food supply Hypercholesterolemia lcsh:TX341-641 Peripheral blood mononuclear cell Article thyme phenolic compounds Thymus Plant 03 medical and health sciences Double-Blind Method Phenols Humans Transcriptomics Olive Oil Gene 030109 nutrition & dietetics Plant Extracts Lipid Metabolism 030104 developmental biology Gene Expression Regulation chemistry functional virgin olive oil Thyme phenolic compounds Biomarkers cholesterol efflux Food Science Lipoprotein |
| Zdroj: | Nutrients Volume 11 Issue 8 Digital.CSIC. Repositorio Institucional del CSIC instname Nutrients, Vol 11, Iss 8, p 1732 (2019) RIUR. Repositorio Institucional de la Universidad de La Rioja r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Recercat. Dipósit de la Recerca de Catalunya Repositorio Abierto de la UdL Universitad de Lleida |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11081732 |
| Popis: | The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benefits are not fully understood. Our aim was to determine whether these functional VOOs could enhance the expression of cholesterol efflux-related genes. In a randomized, double-blind, crossover, controlled trial, 22 hypercholesterolemic subjects ingested for three weeks 25 mL/day of: (1) a functional VOO enriched with olive oil PCs (500 mg/kg) (2) a functional VOO enriched with olive oil (250 mg/kg) and thyme PCs (250 mg/kg FVOOT), and (3) a natural VOO (olive oil PCs: 80 mg/kg, control intervention). We assessed whether these interventions improved the expression of cholesterol efflux-related genes in peripheral blood mononuclear cells by quantitative reverse-transcription polymerase chain reactions. The FVOOT intervention upregulated the expression of CYP27A1 (P = 0.041 and P = 0.053, versus baseline and the control intervention, respectively), CAV1 (P = 0.070, versus the control intervention), and LXR&beta RXR&alpha and PPAR&beta /&delta (P = 0.005, P = 0.005, and P = 0.038, respectively, relative to the baseline). The consumption of a functional VOO enriched with olive oil and thyme PCs enhanced the expression of key cholesterol efflux regulators, such as CYP27A1 and nuclear receptor-related genes. |
| Databáze: | OpenAIRE |
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