Changes in serum histologic surrogate markers and procollagen III N-terminal peptide as independent predictors of HBeAg loss in patients with chronic hepatitis B during entecavir therapy
| Autor: | Kee Myung Lee, Jae Youn Cheong, Jee Hoon Koo, In Sung Kim, Jin Hong Kim, Dong Hoon Kim, Sung Won Cho, Kwang Jae Lee, Soon Sun Kim, Myoung Hee Lee, Byung Moo Yoo |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Hepatitis B virus medicine.medical_specialty Guanine Multivariate analysis Clinical Biochemistry Inflammation Antiviral Agents Gastroenterology chemistry.chemical_compound Internal medicine Hyaluronic acid Humans Medicine Hepatitis B e Antigens Hyaluronic Acid Retrospective Studies TIMP1 Tissue Inhibitor of Metalloproteinase-1 Keratin-18 biology business.industry Haptoglobin Retrospective cohort study General Medicine Entecavir Middle Aged Hepatitis B Fibrosis Peptide Fragments HBeAg chemistry Immunology biology.protein Matrix Metalloproteinase 2 Female medicine.symptom business Biomarkers Procollagen medicine.drug |
| Zdroj: | Clinical Biochemistry. 45:31-36 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/j.clinbiochem.2011.09.023 |
| Popis: | Objectives The aims of this study were to determine the changes in serum histologic surrogate markers and to identify the serum markers predicting treatment response in patients with chronic hepatitis B (CHB) during entecavir treatment. Design and methods Sixty CHB patients who received entecavir for 12 months were included. We assessed serum markers of liver fibrosis and/or inflammation at baseline and after 12 months of entecavir treatment. Results The procollagen III N-terminal peptide (PIIINP) and TIMP1, MMP2, hyaluronic acid and cytokeratin 18 fragment levels were significantly decreased and the haptoglobin level was significantly increased from baseline after entecavir treatment. Multivariate analysis identified PIIINP (P = 0.028) and the initial virologic response (P = 0.019) as independent predictors of HBeAg loss. Conclusion During entecavir treatment, most serum markers of liver fibrosis and inflammation improved in patients with CHB. The PIIINP level at baseline and the initial virologic response are independent predictors of HBeAg loss. |
| Databáze: | OpenAIRE |
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