Cytotoxicity of naturally occurring rhamnofolane diterpenes from Jatropha curcas
| Autor: | En-Qian Liu, Ming-Hua Qiu, Yan Li, Xu-Yang Li, Yuan-Feng Yang, Lin Zhou, Zhong-Rong Li, Jie-Qing Liu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Stereochemistry
Molecular Conformation Crystallographic data HL-60 Cells Jatropha Plant Science Horticulture Crystallography X-Ray Ring (chemistry) Plant Roots Biochemistry Structure-Activity Relationship Botany Humans Cytotoxicity Nuclear Magnetic Resonance Biomolecular Molecular Biology Molecular Structure biology Chemistry General Medicine biology.organism_classification Antineoplastic Agents Phytogenic Female Diterpenes Drug Screening Assays Antitumor Jatropha curcas Human cancer Drugs Chinese Herbal |
| Zdroj: | Phytochemistry. 96:265-272 |
| ISSN: | 0031-9422 |
| Popis: | Twelve rhamnofolane diterpenoids, including curcusecons A-E with unusual seco-rhamnofolane skeletons, curcusones F-J, 4-epi-curcusone E, and 3-dehydroxy-2-epi-caniojane, together with seven known analogues, curcusones A-E, jatrogrossidione, and 2-epi-jatrogrossidione, were isolated from the roots of Jatropha curcas. Their structures were determined by extensive spectroscopic methods, and the relative stereochemistry of curcusecon B was further confirmed by X-ray crystallographic data. Their cytotoxity against five human cancer cells was studied and the results indicated that the dienone system in ring B was essential for cytotoxicity of these compounds. (C) 2013 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect