An Intravenous Bolus of Epa
| Autor: | Mélanie Burban, Valérie B. Schini-Kerth, Anne Olland, Grégory Meyer, Florence Toti, François Severac, Blandine Yver, Julie Boisramé-Helms, Ferhat Meziani |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Mean arterial pressure Docosahexaenoic Acids Myocardial Infarction Ischemia Hemodynamics Myocardial Reperfusion Injury 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Bolus (medicine) Internal medicine medicine Animals Myocardial infarction Rats Wistar biology business.industry Troponin I medicine.disease Rats 3. Good health Nitric oxide synthase Oxidative Stress 030104 developmental biology Eicosapentaenoic Acid chemistry Anesthesia Injections Intravenous Emergency Medicine biology.protein Cardiology Nitric Oxide Synthase business Ex vivo |
| Zdroj: | Shock. 46:549-556 |
| ISSN: | 1073-2322 |
| Popis: | INTRODUCTION Enriching the diet with Omega-3 for several weeks improves myocardial resistance to ischemia-reperfusion (IR) in rats. However, patients with myocardial infarction requiring an emergency reperfusion cannot be pretreated with such a diet. The objective of our study was to describe the effects of an intravenous Omega-3 bolus before reperfusion in a rat model of myocardial IR. METHODS In a rat model of acute myocardial IR, an intravenous Omega-3 bolus (EPA:DHA 6:1), associated or not with iodinated contrast media, was administered after a 30-min ischemia, before reperfusion. Hemodynamic parameters were assessed. Circulating procoagulant microparticles were phenotyped. Vascular and heart inflammation, superoxide anion, and nitric oxide were measured. Ex vivo vascular reactivity was performed with a pharmacological selective inhibitor of inductible nitric oxide synthase. Cardiac troponin I (cTn-I) plasma levels were measured. RESULTS Compared with untreated IR rats, an Omega-3 bolus before reperfusion significantly decreased the IR syndrome, improving mean arterial pressure (114 ± 9 vs. 61 ± 17 mmHg 4 h after reperfusion, P |
| Databáze: | OpenAIRE |
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