CT assessment of tumor heterogeneity and the potential for the prediction of human papillomavirus status in oropharyngeal squamous cell carcinoma
| Autor: | Francesco Mungai, Vittorio Miele, Valentina Berti, Isacco Desideri, Giovanni Battista Verrone, Gloria Addeo, Luigi Bonasera, Michele Pietragalla |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Oncology medicine.medical_specialty Logistic regression Tumor heterogeneity 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Human papillomavirus Oropharyngeal squamous cell carcinoma Correlation of Data Aged Neoplasm Staging Retrospective Studies Neuroradiology Squamous Cell Carcinoma of Head and Neck business.industry Papillomavirus Infections Cancer General Medicine Middle Aged medicine.disease Oropharyngeal Neoplasms Oropharyngeal Carcinoma 030220 oncology & carcinogenesis Female medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | La radiologia medica. 124:804-811 |
| ISSN: | 1826-6983 0033-8362 |
| Popis: | The aim of this study is to find a correlation between tumoral heterogeneity of squamous cell carcinoma of the oropharynx and human papillomavirus (HPV) status and to determine whether analysis of texture features of primary lesion on contrast-enhanced CT (CECT) images can be useful in predicting the HPV positivity. Fifty patients with diagnosis of oropharyngeal carcinoma and pre-treatment CECT were included; tumoral heterogeneity of each lesion was evaluated by extracting quantitative texture parameters of first and higher orders. T test and logistic regression were conducted to evaluate the effects of different textural characteristics. There were 35 HPV+ and 15 HPV− lesions. Statistically significant (p |
| Databáze: | OpenAIRE |
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